Difference between revisions of "Colitis, Granulomatous"
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Latest revision as of 12:52, 7 January 2011
- Affects the horse.
- Usually young to middle age adults.
- Unknown cause.
- Is a one-off occurence rather than a herd problem.
- As in Johnes Diseaase, there is chronic ongoing diarrhoea with eventual death.
- Thickening of mucosa is seen mainly in the caecum and colon.
- Lamina propria contains granulomatous inflammatory tissue (as in Johne's Disease).
- Sometimes large numbers of eosinophils are seen.
- Mesenteric lymph nodes are very large.
- At laparotomy lymph node appears like lymphosarcoma (very large).
- Cannot do much to remedy the condition once it has started.
- Progresses to death.
Proposed Pathogenesis
- Hypersensitivity reaction to trichoneme parasite?
- Possibly an idiosyncratic response to the encysted larvae.
- Dysbacteriosis or disordered immune response?