Difference between revisions of "Category:Autoimmune Diseases"

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|pagetitle =Autoimmune Diseases
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<categorytree mode=pages>Autoimmune Diseases</categorytree>
  
==[[Antibody Mediated Autoimmune Diseases]]==
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==Cell mediated autoimmune diseases==
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[[Category:Immunological Disorders]]
[[Image:Rheumatoid Arthritis Type IV hypersensitivity.jpg|right|thumb|150px|Rheumatoid Arthritis-Brian Catchpole RVC 2008]]
 
[[Image:Diabetes Mellitus Type IV hypersensitivity.jpg|right|thumb|150px|Diabetes Mellitus-Brian Catchpole RVC 2008]]
 
 
 
===1. Rheumatoid arthritis===
 
 
 
'''Pathogenesis:'''
 
 
 
* [[Type IV Hypersensitivity - WikiBlood|Type IV hypersensitivity]]: CD4 Th-1 cell mediated.
 
* Macrophages phagocytose self antigens and can present peptides on their MHC Class II molecules. The autoreactive TH-1 cells release IFN-gamma which activates macrophages to release prostaglandins, MMP enzymes and TNF-alpha (pro-inflammatory mediator), see diagram. These cytokines cause inflammation and tissue destruction.
 
 
 
===2. Diabetes Mellitus type I===
 
'''Pathogenesis:'''
 
 
 
* [[Type IV Hypersensitivity - WikiBlood|Type IV hypersensitivity]]
 
* The CTLs think that all the beta cells in the pancreas are infected by a virus, as it wrongly detects a self antigen presented by the MHC class I on the surface of the cell as foreign.
 
* Autoreactive CD8+ CTLs are inadvertently activated, destroying the beta cells, thus preventing the secretion of insulin and causing diabetes type 1 (see diagram).
 
 
 
===3. Hypothyroidism (lymphocytic throiditis)===
 
 
 
'''Pathogenesis:''' [[Type IV Hypersensitivity - WikiBlood|Type IV hypersensitivity]]
 
 
 
* T cell mediated
 
 
 
===4. Hypoadrenocorticism (Addisons disease)===
 
 
 
'''Pathogenesis:''' [[Type IV Hypersensitivity - WikiBlood|Type IV hypersensitivity]]
 
 
 
[[Category:Lymphoreticular and Haemopoietic Diseases]]
 
[[Category:Immunology]]
 

Latest revision as of 12:48, 18 August 2010

Subcategories

This category has the following 2 subcategories, out of 2 total.

Pages in category "Autoimmune Diseases"

This category contains only the following page.