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==Introduction==
 
==Introduction==
Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the [[Eosinophils|eosinophil]]. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a [[Category:Hypersensitivity|hypersensitivity]] reaction to an unidentified allergen such as microfilariae of [[Heartworm|heartworms]], [[Lungworm|lungworms]], chronic bacterial or fungal infections (eg, histoplasmosis, [[Aspergillosis|aspergillosis]]), viruses, external antigens, and unknown precipitating factors.<br>  
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Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the [[Eosinophils|eosinophil]]. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a [[:Category:Hypersensitivity|hypersensitivity]] reaction to an unidentified allergen such as microfilariae of [[Heartworm|heartworms]], [[Lungworm|lungworms]], chronic bacterial or fungal infections (eg, histoplasmosis, [[Aspergillosis|aspergillosis]]), viruses, external antigens, and unknown precipitating factors.<br>  
 
'''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is characterized by the development of nodules and hilar lymphadenopathy. It is most often associated with a hypersensitivity reaction to microfilarie in heartworm infection.  
 
'''Eosinophillic pulmonary granulomatosis''' is a severe type of PIE seen in dogs and is characterized by the development of nodules and hilar lymphadenopathy. It is most often associated with a hypersensitivity reaction to microfilarie in heartworm infection.  
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[[Category:Allergic Respiratory Diseases]][[Category:Expert_Review]]
 
[[Category:Allergic Respiratory Diseases]][[Category:Expert_Review]]
 
[[Category:Immunological Diseases - Dog]][[Category:Respiratory Diseases - Dog]]
 
[[Category:Immunological Diseases - Dog]][[Category:Respiratory Diseases - Dog]]
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[[Category:Type I Hypersensitivity Diseases]]
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[[Category:Bronchi and Bronchioles - Pathology]]
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[[Category:Respiratory System - Inflammatory Pathology]]
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