Author, Donkey, Bureaucrats, Administrators
53,803
edits
Changes
no edit summary
{{review}}
{{OpenPagesTop}}
==Introduction==
==Introduction==
'''Leptospirosis''' is a disease caused by the bacteria [[Leptospira|''Leptospira interrogans'']]. It affects domestic species, wildlife and has zoonotic potential. There are several different serovars which vary in pathogenesis and their host specificity. Most infections result in a self limiting pyrexia and anorexia, however occasionally the condition is more serious causing '''recurrent uveitis''', '''abortion''', or '''renal and hepatic disease'''. Recurrent uveitis is the most important clinical syndrome associated with Leptospirosis. The association has been well recognised for many years, originally thought to be an immune-mediated disease involving a cross reaction between antibodies against leptospira and ocular tissues. There is now additional evidence that live leptospira persist in the ocular fluids, providing continuous antigetic stimulation resulting in high antibodies titres in aqueous humour in comparison to the serum, suggesting that the eye is an immune privileged site.
'''Leptospirosis''' is a disease caused by the bacteria [[Leptospira|''Leptospira interrogans'']]. It affects domestic species, wildlife and has zoonotic potential. There are several different serovars which vary in pathogenesis and their host specificity. Most infections result in a self limiting pyrexia and anorexia, however occasionally the condition is more serious causing '''recurrent uveitis''', '''abortion''', or '''renal and hepatic disease'''. Recurrent uveitis is the most important clinical syndrome associated with Leptospirosis. The association has been well recognised for many years, originally thought to be an immune-mediated disease involving a cross reaction between antibodies against leptospira and ocular tissues. There is now additional evidence that live leptospira persist in the ocular fluids, providing continuous antigetic stimulation resulting in high antibodies titres in aqueous humour in comparison to the serum, suggesting that the eye is an immune privileged site.
Prognosis depends on the severity of the disease and the degree of organ involvement. In ophthalmic cases recovery may be incomplete, alternating between times of acute disease and symptom-free periods. In cases of abortion the mare will usually recover without complications. Prognosis is guarded for the renal, hepatic and neonatal syndromes in acute and severe cases.
Prognosis depends on the severity of the disease and the degree of organ involvement. In ophthalmic cases recovery may be incomplete, alternating between times of acute disease and symptom-free periods. In cases of abortion the mare will usually recover without complications. Prognosis is guarded for the renal, hepatic and neonatal syndromes in acute and severe cases.
==Literature Search==
{{Learning
|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=leptospir*&occuring1=title&rowId=2&options2=AND&q2=horses&occuring2=od&rowId=3&options3=AND&q3=&occuring3=freetext&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all&x=38&y=14 Leptospirosis in horses publications]
}}
==References==
==References==
* Brown, C.M, Bertone, J.J. (2002) '''The 5-Minute Veterinary Consult- Equine'''', Lippincott, Williams & Wilkins''
* Brown, C.M, Bertone, J.J. (2002) '''The 5-Minute Veterinary Consult- Equine'''', Lippincott, Williams & Wilkins''
* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
* Robinson, N.E., Sprayberry, K.A. (2009) '''Current Therapy in Equine Medicine''' (Sixth Edition) ''Saunders Elsevier''
* Robinson, N.E., Sprayberry, K.A. (2009) '''Current Therapy in Equine Medicine''' (Sixth Edition) ''Saunders Elsevier''
{{review}}
{{OpenPages}}
[[Category:Expert_Review]]
[[Category:Expert_Review]]