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− | ==Introdcution== | + | ==Introduction== |
| Amyloid infiltration occurs in all species - amaloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli, | | Amyloid infiltration occurs in all species - amaloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli, |
| [[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords). | | [[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords). |
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| Affected organs are non-functional and appear waxy and pale. | | Affected organs are non-functional and appear waxy and pale. |
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| + | *Amyloid is an insoluble protein that can accumulate in the kidney and compress the glomerulus, interfering with its normal function. |
| + | *Hypoproteinaemia and nephrotic syndrome can result due to substantial protein loss in the urine. |
| + | *Causes can be idiopathic or associated with underlying chronic inflammatory conditions. |
| + | '''Gross pathology''' |
| + | *Kidneys are firm, enlarged, and pale. Affected glomeruli may be seen as yellowish spots in the cortex. |
| + | *Amyloid can be visualised by treating the freshly cut surface of the kidneys with iodine. |
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| + | '''Histopathology''' |
| + | *Amyloid stains pink with congo red. |
| + | *Presence of a pink, homogenous material replacing the epithelium and endothelium of the glomerulus. |
| + | <center><gallery> |
| + | Image:Congo red.jpg|'''Amyloidosis Stained with Congo Red''' <br> Susan Rhind, University of Edinburgh |
| + | Image:Amyloidosis_histology.jpg|'''Amyloidosis Histology''' <br> Susan Rhind University of Edinburgh |
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| + | </gallery></center> |
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| ==Test yourself with the Vascular Pathology Flashcards== | | ==Test yourself with the Vascular Pathology Flashcards== |
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| [[Vascular Pathology Flashcards]] | | [[Vascular Pathology Flashcards]] |
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| [[Category:Liver_-_Storage_Diseases]] | | [[Category:Liver_-_Storage_Diseases]] |
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| [[Category:Cardiovascular_System_-_Degenerative_Pathology]][[Category:Cardiovascular_System_-_Vascular_Pathology]][[Category:Arterial_Pathology]] | | [[Category:Cardiovascular_System_-_Degenerative_Pathology]][[Category:Cardiovascular_System_-_Vascular_Pathology]][[Category:Arterial_Pathology]] |
| + | [[Category:Glomerular Disease]] |
| + | [[Category:To Do - Urinary]] |