Changes

*'''[[Fluoxetine]]''' (EU and USA license for the treatment of separation anxiety in dogs, when used in combination with behavioural therapy. Subsequently withdrawn from European market).

*'''[[Fluoxetine]]''' (EU and USA license for the treatment of separation anxiety in dogs, when used in combination with behavioural therapy. Subsequently withdrawn from European market).

A range of other drugs are used to treat behavioural conditions, including beta-adrenoceptor antagonists, benzodiazepines, azapirones, anticonvulsants and triazolopyridines.

A range of other drugs are used to treat behavioural conditions, including beta-adrenoceptor antagonists, benzodiazepines, azapirones, anticonvulsants and triazolopyridines.

Some of these drugs are licensed for use in a companion animal species for another condition, but many are not licensed for use in any companion animal species.  

Some of these drugs are licensed for use in a companion animal species for another condition, but many are not licensed for use in any companion animal species.  

| '''Tranquillisers''' || Acepromazine || Sedation/restraint (no specific indication in behavioural therapy) || Hypotension, CNS stimulation, contradictory responses. Caution in boxers and greyhounds

| '''Tranquillisers''' || Acepromazine || Sedation/restraint (no specific indication in behavioural therapy) || Hypotension, CNS stimulation, contradictory responses. Caution in boxers and greyhounds

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| '''Benzodiazepines '''|| Alprazolam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Oxazepam || [[Feline Fear and Stress|Acute anxiety, panic, short-term management of noise phobias]]  || Hepatic necrosis after oral dosing (potentially fatal), Sedation, ataxia, increased appetite, paradoxical excitation

| '''Benzodiazepines '''|| Alprazolam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Oxazepam || [[Feline Fear and Stress|Acute anxiety, panic, short-term management of noise phobias]]  || Hepatic necrosis after oral dosing in cats (potentially fatal), Sedation, ataxia, increased appetite, paradoxical excitation, amnesia

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| '''Tricyclic Antidepressants (TCAs)''' || Amitriptyline, [[Clomipramine]] || Anxiety, separation anxiety, canine and [[Feline Aggression|feline fear aggression]], [[Indoor Marking - Cat|feline urine marking]], [[Feline Grooming Disorders|feline compulsive grooming]], stereotypy, some narcoleptic disorders || Sedation, gastrointestinal (GI) effects, dry mouth, increased thirst, urinary retention

| '''Tricyclic Antidepressants (TCAs)''' || Amitriptyline, [[Clomipramine]] || Anxiety, separation anxiety, canine and [[Feline Aggression|feline fear aggression]], [[Indoor Marking - Cat|feline urine marking]], [[Feline Grooming Disorders|feline compulsive grooming]], stereotypy, some narcoleptic disorders || Sedation, gastrointestinal (GI) effects, dry mouth, increased thirst, urinary retention

| '''Selective Serotonin Reuptake Inhibitors (SSRIs)''' || [[Fluoxetine]], Fluvoxamine, Paroxetine, Sertraline || [[Feline Aggression|Aggression]], canine separation anxiety, [[Feline Compulsive Disorders|compulsive disorders]], [[Indoor Marking - Cat|feline urine marking]] || Lethargy, inappetence, anorexia, GI effects

| '''Selective Serotonin Reuptake Inhibitors (SSRIs)''' || [[Fluoxetine]], Fluvoxamine, Paroxetine, Sertraline || [[Feline Aggression|Aggression]], canine separation anxiety, [[Feline Compulsive Disorders|compulsive disorders]], [[Indoor Marking - Cat|feline urine marking]] || Lethargy, inappetence, anorexia, GI effects

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| '''Beta Blockers''' || Propranolol || Canine fear aggression, noise phobia || Bradycardia, lethargy, hypotension, syncope

| '''Beta Blockers''' || Propranolol || Situational anxiety, social anxiety, augmentation therapy for SRI/SSRIS drugs || Bradycardia, lethargy, hypotension, syncope

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| '''Azapirones''' || Busiprone || Phobia, anxiety, feline urine marking, interact aggression || Uncommon, not sedating

| '''Azapirones''' || Busiprone || Anxiety, feline urine marking, interact aggression || Uncommon, not sedating

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| '''Triazolopyridines''' || Trazodone || ||

| '''Triazolopyridines''' || Trazodone || Anxiety, phobia, separations anxiety, used primarily as an augmentation for other psychoactive drug therapies||

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| '''Anticonvulsants''' || Carbamazepine, Gabapentin, Levetiracetam, Phenobarbital, Potassium bromide || Canine and feline compulsive tail chasing, unprovoked canine rage aggression || Lethargy, ataxia, polyuria, polydipsia, polyphagia

| '''Anticonvulsants''' || Carbamazepine, Gabapentin, Levetiracetam, Phenobarbital, Potassium bromide || Behavioural problems arising from focal seizures (e.g. aggression, tail chasing) || Lethargy, ataxia, polyuria, polydipsia, polyphagia

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| '''Glial Modulators''' || Propentofylline || Reduced activity in dogs (as an adjunct therapy for dogs with cognitive dysfunction syndrome) ||

| '''Glial Modulators''' || Propentofylline || ||

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| '''Monoamine Oxidase Inhibitors (MAO-Is)''' || [[Selegiline]] || Canine and feline cognitive dysfunction syndrome, fear related problems, spraying, hyperactivity, compulsive/stereoptypical disorders, specific phobias || GI effects, restlessness or lethargy, anorexia

| '''Monoamine Oxidase Inhibitors (MAO-Is)''' || [[Selegiline]] || Canine and feline cognitive dysfunction syndrome, fear related problems, spraying, hyperactivity, compulsive/stereoptypical disorders, specific phobias || GI effects, restlessness or lethargy, anorexia