Changes

Lysine plays a key role in determining the secondary structure of proteins. It is a precursor of hydroxylysine, a key component of collagen, and of carnitine, which plays an important role in energy metabolism by transporting fatty acids into the mitochondria. Lysine can be de-aminated by intestinal bacterial to form the foul-smelling compound cadaverine<ref name="NRC"/>.

Lysine plays a key role in determining the secondary structure of proteins. It is a precursor of hydroxylysine, a key component of collagen, and of carnitine, which plays an important role in energy metabolism by transporting fatty acids into the mitochondria. Lysine can be de-aminated by intestinal bacterial to form the foul-smelling compound cadaverine<ref name="NRC"/>.

====Cats:====  

====Cats:====  

Lysine antagonises arginine induced promotion of herpes virus in vitro<ref>Maggs DJ, et al. Effects of L-lysine and L-arginine on in vitro replication of feline herpesvirus type-1. AJVR 2000;61:1474-1478.</ref>, and oral supplementation (400 mg PO q 24h to 500 mg PO q 12h) has been shown to decrease both viral shedding and severity of conjunctivitis in [[Feline Herpesvirus 1|herpes virus]]-infected cats<ref>Maggs DJ, et al. Efficacy of oral supplementation with L-lysine in cats latently infected with feline herpesvirus. AJVR 2003;64:37-42.</ref><ref>Stiles J, et al. Effect of oral administration of L-lysine on conjunctivitis caused by feline herpesvirus in cats. AJVR 2002;63:99-103.</ref>. However other studies<ref>Maggs DJ, et al. Effects of dietary lysine supplementation in cats with enzootic upper respiratory disease. J Fel Med Surg 2007;9:97-108.</ref><ref>Drazenovich T, et al. Effects of dietary lysine supplementation on upper respiratory and ocular disease and detection of infectious organisms in cats within an animal shelter. AJVR 200;70:1391-400.</ref> have not shown an effect of lysine supplementation on non-ophthalmological herpes virus, [[Chlamydophila felis|Chlamydophila]], or [[Feline Calicivirus|calicivirus]] shedding or on the severity of upper respiratory infection signs.

Lysine antagonises arginine induced promotion of [[Feline Herpesvirus 1|herpes virus]] in vitro<ref>Maggs DJ, et al. Effects of L-lysine and L-arginine on in vitro replication of feline herpesvirus type-1. AJVR 2000;61:1474-1478.</ref>, and oral supplementation (400 mg PO q 24h to 500 mg PO q 12h) has been shown to decrease both viral shedding and severity of [[Conjunctivitis|conjunctivitis]] in herpes virus-infected cats<ref>Maggs DJ, et al. Efficacy of oral supplementation with L-lysine in cats latently infected with feline herpesvirus. AJVR 2003;64:37-42.</ref><ref>Stiles J, et al. Effect of oral administration of L-lysine on conjunctivitis caused by feline herpesvirus in cats. AJVR 2002;63:99-103.</ref>. However other studies<ref>Maggs DJ, et al. Effects of dietary lysine supplementation in cats with enzootic upper respiratory disease. J Fel Med Surg 2007;9:97-108.</ref><ref>Drazenovich T, et al. Effects of dietary lysine supplementation on upper respiratory and ocular disease and detection of infectious organisms in cats within an animal shelter. AJVR 200;70:1391-400.</ref> have not shown an effect of lysine supplementation on non-ophthalmological herpes virus, [[Chlamydophila felis|Chlamydophila]], or [[Feline Calicivirus|calicivirus]] shedding or on the severity of upper respiratory infection signs.

==Consequences of Lysine Deficiency==

==Consequences of Lysine Deficiency==