Changes

=== Pelger-Huet anomaly ===

=== Pelger-Huet anomaly ===

[[File:NWLLabfacts 34.jpg|thumb|Pelger-Huet Anomaly NationWide Laboratories]]

[[File:NWLLabfacts 34.jpg|thumb|'''Pelger-Huet Anomaly''' ©NationWide Laboratories 2017]]

This is an inherited disorder of leucocytes in dogs, cats, rabbits, horses and humans, characterised by hyposegmentation of granulocytes. Mature neutrophils have the appearance of metamyelocytes and the overall picture mimics a severe degenerative left shift, although nuclear chromatin is mature and toxic changes are not evident. No clinical signs are evident in heterozygous individuals, homozygous individuals die in utero or perinatally.  

This is an inherited disorder of leucocytes in dogs, cats, rabbits, horses and humans, characterised by hyposegmentation of granulocytes. Mature neutrophils have the appearance of metamyelocytes and the overall picture mimics a severe degenerative left shift, although nuclear chromatin is mature and toxic changes are not evident. No clinical signs are evident in heterozygous individuals, homozygous individuals die in utero or perinatally.  

=== Chediak-Higashi syndrome ===

=== Chediak-Higashi syndrome ===

[[File:NWLLabfacts 35.jpg|thumb|Chediak-Higashi Syndrome NationWide Laboratories]]

[[File:NWLLabfacts 35.jpg|thumb|'''Chediak-Higashi''' Syndrome ©NationWide Laboratories 2017]]

This is reported in Persian cats and cattle. Affected individuals exhibit partial albinism, increased susceptibility to infections and bleeding diatheses. Large membrane bound vesicles are present in many cells including leucocytes and melanocytes. These result from the abnormal fusion of lysosomes during cell development. Neutrophils and eosinophils contain giant granules which look like inclusions; they show decreased mobility, defective phagocytic and bactericidal responses. Bleeding tendencies are due to the absence in platelets of normal dense granules.  

This is reported in Persian cats and cattle. Affected individuals exhibit partial albinism, increased susceptibility to infections and bleeding diatheses. Large membrane bound vesicles are present in many cells including leucocytes and melanocytes. These result from the abnormal fusion of lysosomes during cell development. Neutrophils and eosinophils contain giant granules which look like inclusions; they show decreased mobility, defective phagocytic and bactericidal responses. Bleeding tendencies are due to the absence in platelets of normal dense granules.