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** '''Zona protein 3''': binds to proteins on the spermatozoal membrane.
 
** '''Zona protein 3''': binds to proteins on the spermatozoal membrane.
 
* The sperm plasma membrane contains two zona binding sites:
 
* The sperm plasma membrane contains two zona binding sites:
** Primary zona binding region: responsible for adherence to the zona pellucida.
+
** '''Primary zona binding region''': responsible for adherence to the zona pellucida.
** Acrosome reaction promoting ligand: when this binds to the zona protein 3, signal transduction occurs to initiate the acrosome reaction.
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** '''Acrosome reaction promoting ligand''': when this binds to the zona protein 3, signal transduction occurs to initiate the acrosome reaction.
 
* After the acrosome reaction, zona penetration is a rapid process (minutes).
 
* After the acrosome reaction, zona penetration is a rapid process (minutes).
 
* The acrosome reaction releases enzymes:
 
* The acrosome reaction releases enzymes:
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