Changes

As well as reducing the reuptake of water they also increase renal blood flow via [[The Effects of Nitrous Oxide and Prostaglandins on GFR#Prostaglandins|prostaglandin mediated vasodilation]].  This increases filtration to help lessen fluid retention.

As well as reducing the reuptake of water they also increase renal blood flow via [[The Effects of Nitrous Oxide and Prostaglandins on GFR#Prostaglandins|prostaglandin mediated vasodilation]].  This increases filtration to help lessen fluid retention.

Loop diuretics tend to be bound to plasma protein and therefore are not filtered.  They enter the tubule via secretion by the [[Secretion Into The Renal Tubules - Physiology#Primary Active Secretion - Organic Acids and Bases|organic acid transport mechanisms]].

Loop diuretics tend to be bound to plasma protein and therefore are not filtered.  They enter the tubule via secretion by the [[Reabsorption and Secretion Along the Proximal Tubule - Anatomy & Physiology#Primary Active Secretion - Organic Acids and Bases|organic acid transport mechanisms]].

===Thiazides===

===Thiazides===

This class of drugs works on the proximal portion of the [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Distal Tubule|distal convoluted tubule]] and inhibits the sodium chloride co-transporter in the apical membrane. As a result they increase the potassium loss - see picture. They are less effective than loop diuretics but are better tolerated.   

This class of drugs works on the proximal portion of the [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Distal Tubule|distal convoluted tubule]] and inhibits the sodium chloride co-transporter in the apical membrane. As a result they increase the potassium loss - see picture. They are less effective than loop diuretics but are better tolerated.   

As with loop diuretics thiazides are excreted into the tubules via [[Secretion Into The Renal Tubules - Physiology#Primary Active Secretion - Organic Acids and Bases|secretion]].

As with loop diuretics thiazides are excreted into the tubules via [[Reabsorption and Secretion Along the Proximal Tubule - Anatomy & Physiology#Primary Active Secretion - Organic Acids and Bases|secretion]].

===Potassium Sparing Diuretics===

===Potassium Sparing Diuretics===