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**When activated by cytokines, killing mechanisms using free radicals and O2-independent toxins (e.g. nitric oxide) are enhanced
 
**When activated by cytokines, killing mechanisms using free radicals and O2-independent toxins (e.g. nitric oxide) are enhanced
 
*'''[[Neutrophils|Neutrophils]]'''- similar properties to macrophages
 
*'''[[Neutrophils|Neutrophils]]'''- similar properties to macrophages
**Activated by cytokines such as TNF-alpha, IFN-γ and GM-CSF, [[[[Neutrophils|Neutrophils]] - WikiBlood|neutrophils]] produce a more intense respiratory burst and extracellular killing is mediated by H2O2
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**Activated by cytokines such as TNF-alpha, IFN-γ and GM-CSF, [[Neutrophils|Neutrophils]] produce a more intense respiratory burst and extracellular killing is mediated by H2O2
 
**Present in parasite-infected inflammatory lesions
 
**Present in parasite-infected inflammatory lesions
 
**Express Fc and complement receptors- can participate in antibody-dependent cell-mediated cytotoxicity
 
**Express Fc and complement receptors- can participate in antibody-dependent cell-mediated cytotoxicity
*'''Eosinophils'''- less phagocytic than [[[[Neutrophils|Neutrophils]] - WikiBlood|neutrophils]], but important in the destruction of larger parasites
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*'''Eosinophils'''- less phagocytic than [[Neutrophils|Neutrophils]], but important in the destruction of larger parasites
 
**Most activity is controlled by antigen-specific mechanisms, e.g. binding to worms coated with [[IgG]]/[[IgE]] increases degranulation
 
**Most activity is controlled by antigen-specific mechanisms, e.g. binding to worms coated with [[IgG]]/[[IgE]] increases degranulation
 
**The killing of some larvae is enhanced by the activity of mast cells, e.g. antigens released by S. mansoni cause [[IgE]]-dependent degranulation of mast cells, the products of which selectively attract eosinophils
 
**The killing of some larvae is enhanced by the activity of mast cells, e.g. antigens released by S. mansoni cause [[IgE]]-dependent degranulation of mast cells, the products of which selectively attract eosinophils
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