Difference between revisions of "Inclusion Body Rhinitis"

Revision as of 14:34, 15 February 2011

Inclusion body rhinitis (Image sourced from Bristol Biomed Image Archive with permission)

Herpesviridae, porcine cytomegalovirus
Disease of suckling piglets 1-5 wks of age
Clinical signs: those associated with acute/subacute rhinitis (ie: serous nasal discharge, progressing to catarrhal or purulent discharge with time and secondary bacterial infections; sneezing; pyrexia), fever in young piglets (3-8wks old)
May progress to sinusitis, otitis media or pneumonia
Morbitity high, mortality low
Gross pathology - catarrhal discharge becoming purulent (secondary infection)
Histology:
- Large basophilic intranuclear inclusion bodies in the surface and subepithelium of nasal and sinus glandular epithelium with lymphocytic infiltration of the mucosa
- Bursting of nucleus with cell necrosis and sloughing of necrotic epithelium
Can develop viraemic stage, with inclusions and focal necrotising lesions in other organs eg: renal tubular epithelium
- Usually younger piglets, can die during this phase
Usually resolves if uncomplicated but rhinitis may persist if secondary infection is present
May persist in pulmonary macrophages

@@ Line 9: / Line 9: @@
 *Gross pathology - catarrhal discharge becoming purulent (secondary infection)
 *Histology:
-**Large basophilic [[Degenerations and Infiltrations - Pathology#Cellular Inclusions|intranuclear inclusion bodies]] in the surface and subepithelium of nasal and sinus glandular epithelium with lymphocytic infiltration of the mucosa
+**Large basophilic [[Cellular Inclusions|intranuclear inclusion bodies]] in the surface and subepithelium of nasal and sinus glandular epithelium with lymphocytic infiltration of the mucosa
 **Bursting of nucleus with cell necrosis and sloughing of necrotic epithelium
 *Can develop viraemic stage, with inclusions and focal necrotising lesions in other organs eg: renal tubular epithelium