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**An adhesin, intimin is required for attachment to enterocytes
**An adhesin, intimin is required for attachment to enterocytes
**Cause attching and effacing lesions in the gut, with necrosis of enterocytes and stunting and fusion of villi
**Cause attching and effacing lesions in the gut, with necrosis of enterocytes and stunting and fusion of villi
*Enteroinvasive ''E. coli'':
*Enteroinvasive ''E. coli'':
**Dysentry-like strains
**Dysentry-like strains
**Disseminated intravascular coagulation and thrombus formation
**Disseminated intravascular coagulation and thrombus formation
**''E. coli'' O157:H7 causes haemorrhagic collitis-haemolytic uraemic syndrome in humans
**''E. coli'' O157:H7 causes haemorrhagic collitis-haemolytic uraemic syndrome in humans
*Cytotoxin necrotising factor-producing ''E. coli''
**
*Oedema disease of pigs:
*Oedema disease of pigs:
**Associated with oedema disease toxin-producing strains of ''E. coli''
**Acute, frequently fatal enterotoxaemia of weaned pigs
**Verotoxin released in the small intestine and carried in the bloodstream
**Associated with particular haemolytic serotypes of ''E. coli''
**Verotoxin (Shiga toxin II e) released in the small intestine and carried in the bloodstream
**Haemolysin production
**Haemolysin production
**Subcutaneous and subserosal oedema
**Peracute disease affecting particulary healthy piglets
**Mortality rate 30%-90%
**Antimicrobial treatment effectic if administered in time
*Haemorrhagic gastroenteritis:
*Haemorrhagic gastroenteritis: