Difference between revisions of "Adrenogenital Syndrome"
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* Appears male with a '''micropenis and scrotum''' | * Appears male with a '''micropenis and scrotum''' | ||
* Both male and female internal genitalia | * Both male and female internal genitalia | ||
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| + | [[Image:Sexual Differentiation adrenogenital syndrome.jpg|right|thumb|250px|<small><center> Schematic showing Genetalia in Adrenogenital Syndrome. Copyright RVC 2008 (Courtesy of Proff.R.Abayesekara (RVC))</center></small>]] | ||
Revision as of 12:09, 3 July 2008
Aetiology
- Genotype is XX as should be female
- Ovaries develop normally
- Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a 21 hydroxylase mutation.
Consequence
- Wolffian Ducts persist due to the presence of Androgens, thus allowing development of male internal and external genitalia.
- Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of female internal genitalia.
Morphology
- Appears male with a micropenis and scrotum
- Both male and female internal genitalia
