Difference between revisions of "Parturition Pharmacological Manipulation - Anatomy & Physiology"
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Prostaglandin F2α and Oxytocin: [[Parturition_-_Coordinated_Myometrial_Contraction_-_Anatomy_%26_Physiology|Uterine contractions]] | Prostaglandin F2α and Oxytocin: [[Parturition_-_Coordinated_Myometrial_Contraction_-_Anatomy_%26_Physiology|Uterine contractions]] | ||
Oxytocin: delivery of the [[Gestation_-Placenta_-_Anatomy_%26_Physiology|Placenta]] | Oxytocin: delivery of the [[Gestation_-Placenta_-_Anatomy_%26_Physiology|Placenta]] | ||
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+ | * Oxytocin and Prostaglandin F2α both signal by the Gαq -> IP3 + DAG pathway to raise intracellular calcium , so are able to effect each other in the Fergusson reflex. | ||
= Drugs Influencing Uterine Activity = | = Drugs Influencing Uterine Activity = |
Revision as of 11:42, 28 July 2008
Why Control Timing of Parturition?
Herds
- Improves supervision to ensure the farmer can be around at the time of parturition.
- Reduces the incidence of parturition at night/weekends which is socially undesirable.
- Aids cross fostering between litters.
- Tightens the calving interval in cattle.
Individuals
- Maternal emergrncy such as abnormal foetal position, bone fracture of the pelvis etc.
- Foetal abnormality, or an oversized foetus.
Disadvantages of Parturition Induction
- Timing may not be absolutely perfect, there is considerable variation in the timing of drug action and effect.
- Premature delivery of small, immature offspring.
- Increased incidence of retained placenta.
- Pharmacological induction can only be used commercially in cattle and pigs. Induction in other species is used only to overcome birth associated problems.
Requirements for Parturition Induction
Prostaglandin F2α: Cervical dilation Prostaglandin F2α and Oxytocin: Uterine contractions Oxytocin: delivery of the Placenta
- Oxytocin and Prostaglandin F2α both signal by the Gαq -> IP3 + DAG pathway to raise intracellular calcium , so are able to effect each other in the Fergusson reflex.