Difference between revisions of "Sertoli Cell Tumour"
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Sertoli cells are those which act as ''nurse cells'' to the developing spermatozoa. The sertoli cells engulf the spermatozoa, are structurally important in the seminiferous tubules and form the blood-testis barrier. | Sertoli cells are those which act as ''nurse cells'' to the developing spermatozoa. The sertoli cells engulf the spermatozoa, are structurally important in the seminiferous tubules and form the blood-testis barrier. | ||
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Treatment involves castration. Metastasis is rare but can occur, in which case chemotherapy is a possible treatment option. | Treatment involves castration. Metastasis is rare but can occur, in which case chemotherapy is a possible treatment option. | ||
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Revision as of 14:21, 21 February 2011
Sertoli cells are those which act as nurse cells to the developing spermatozoa. The sertoli cells engulf the spermatozoa, are structurally important in the seminiferous tubules and form the blood-testis barrier.
Tumours are usually slow growing although 10-20% show malignant characteristics. Neoplasia is predisposed by inguinal or abdominal testes.
Sertoli cell tumours usually present as a feminising syndrome in the elderly dog. Owners may also notice:
- Asymmetric testes.
- Swelling in one testis.
- Infertility/subfertility in a breeding dog.
Treatment involves castration. Metastasis is rare but can occur, in which case chemotherapy is a possible treatment option.