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**''Gasterophilus''
 
**''Gasterophilus''
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'''[[Hypoderma spp.|''Hypoderma spp.'']]
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===''Hypoderma spp.''===
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*Also known as warble flies
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*Important cattle parasites
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**Also parasitise horses, small ruminants and sometimes humans
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*The two main species in cattle are
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**''H. bovis''
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**''H. lineatum''
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*''H. diana'' parasitises deer
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*Infestation is largely confined to the Northern Hemisphere
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'''Recognition'''
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*Large 13-15mm long
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*Similar to bumble bees in appearance
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**Yellow abdomen
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**Band of black hairs
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*1 pair of wings
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'''Life cycle'''
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*Adult flies emerge on warm, sunny days between '''June and August'''
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*White eggs are laid around the belly and legs of the animal
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**Eggs are attached to hairs by cement and a small terminal clasp
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**''H. lineatum'' lays a whole row of eggs as it approaches the animal stealthily
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**''H. bovis'' only deposits a single egg before the animal runs away ('''gadding''') as it makes a loud buzzing noise
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*The adult lives for 3 weeks
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*Females can lay several hundred eggs in their life
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*A few days after eggs are laid, larvae emerge and crawl down the hairs into the hair follicles
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*Larvae penetrate the skin through wounds made by [[Biting Flies|biting flies]]
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*Larvae migrate through the subcutaneous tissue towards the diaphragm
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**Enzymatic secretions and mouth hooks aid larval migration
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*After 3 months larvae reach '''winter resting sites''' where they remain from November to February/March whilst moulting to the L2 stage. These sites are different between the 2 species
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**Epidural fat in the spinal canal for ''H. bovis''
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**Wall of the [[Oesophagus - Anatomy & Physiology|oesophagus]] for ''H. lineatum''
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*Larvae then migrate back to the subcutis along the midline of the back where they bore a breathing hole through the skin and moult to the L3 stage
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**Larvae are palpable as distinct swellings called '''warbles'''
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*L3 larvae emerge after 4-10 weeks where they fall to the ground and pupate under loose vegetation
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*Adult flies emerge from the pupa after 1 month where they copulate, lay eggs and die within 2 weeks
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*''H. lineatum'' are on the wing 6-8 weeks before ''H. bovis''
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*There is only '''1 generation''' of warble flies per year
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'''Pathogenesis'''
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*Causes [[Muscles Inflammatory - Pathology#Arthropods|myositis]]
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*Production losses
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**Condemnation and down-grading of hides
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**Reduced milk yield and reduced weight gain
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**Injury from stock panic
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**Trimmed meat losses from ''H. lineatum''
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***'Butcher's Jelly' around warbles which is green due to mass [[Eosinophils - WikiBlood|eosinophil]] attraction
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*Paraplegia resulting from
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**Toxin release
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**Pressure on the spinal cord (''H. bovis'')
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**Bloat from pressure on the [[Oesophagus - Anatomy & Physiology|oesophageal wall]] (''H. lineatum'')
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'''Control'''
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*Total eradication should be aimed for
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*Old methods include popping out warbles
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**But this could lead to anaphylactic shock
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*[[Ectoparasiticides]]
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**Systemic organophosphorus [[Ectoparasiticides|insecticides]] in pour-on formula
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**Avermectins and milbemycins in pour-on and injectible formulations
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*Timing is crucial for treatment
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**Larvae residing in winter resting sites, if killed, can lead to bloat and paraplegia
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**It is safe to treat in the '''autumn''' before larvae reach their winter resting sites and in the '''spring''' when the warbles have migrated to the midline of the back
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**Ivermectin can be given at any time without risking host infection as larval antigen is released much slower
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'''Legislation in the UK'''
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*'Warble Fly Order 1978' requires all clinically affected animals to be treated
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*Notifiable disease
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*'Warble Fly Infected Area Order 1983'
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*For more information on the warble fly orders, see [http://www.defra.gov.uk/animalh/diseases/notifiable/brucellosis/surveillance.htm| here]
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</big>
 
===''Oestrus ovis''===
 
===''Oestrus ovis''===
  
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