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| | [[Liver Regeneration]] | | [[Liver Regeneration]] |
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| | + | [[Liver Fibrosis]] |
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| − | ===Fibrosis - Repair===
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| − |
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| − | *any hepatic injury of consequence is going to cause a degree of fibrosis when the lesion has resolved
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| − | *the fibrosis comes from the proliferation of the supportive connective tissue in the [[Liver - Anatomy & Physiology|liver]]
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| − | *fibrosis isolates the [[Liver - Anatomy & Physiology|liver]] cells by effectively changing the sinusoids into capillaries
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| − | *when a certain amount of fibrosis occurs, it can be self-perpetuating
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| − | **the end result is a small scarred [[Liver - Anatomy & Physiology|liver]] with functional failure
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| − | ====Histological patterns====
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| − | =====Periacinar fibrosis=====
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| − | *the fibrosis surrounds the hepatic venule (centrilobular vein)
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| − | *can be seen when there is chronic passive congestion with atrophy of the surrounding periacinar hepatocytes and condensation of the remaining connective tissue
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| − | =====Biliary fibrosis=====
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| − | *accompanying inflammation centered on the portal triads
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| − | =====Post necrotic scarring=====
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| − | *following massive necrosis where the necrotic cells are removed and the defect is reapired by fibrosis
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| − | *seen as bands of fibrous tissue
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| − | =====Diffuse fibrosis=====
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| − | *resulting from repeated damage to one or more zones
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| − | *the fibrosis generated proliferates throughout to involve all the tissue
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| | ===Biliary hyperplasia=== | | ===Biliary hyperplasia=== |