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| | ===Viral=== | | ===Viral=== |
| | ====[[Infectious Canine Hepatitis]]==== | | ====[[Infectious Canine Hepatitis]]==== |
| − | *adenovirus
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| − | *also known as Rubarth's Disease, Canine adenovirus infection
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| − | *acute and generalised infection
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| − | *young dogs
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| − | *highly infectious
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| − | *spread via the urine of infected animals over a long period of time
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| − | =====Clinical=====
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| − | *[[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Tonsils - Anatomy & Physiology|tonsils]] are enlarged and reddened, sometimes haemorrhagic
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| − | *recovering animals may show an immune-mediated uveitis with corneal opacity
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| − | =====Gross=====
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| − | *the virus has a tropism for endothelium and hepatocytes
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| − | **widespread haemorrhages, especially on serosal surface
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| − | *distinctly pale mottled appearance
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| − | **from extensive necrosis, characteristically periacinar (centrilobular) in distribution - the reason for the increased susceptibility of this area is not known
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| − | *enlarged
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| − | *friable
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| − | *fibrinous or fibrino-haemorrhagic strands between lobes
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| − | *[[Gall Bladder - Anatomy & Physiology|gall bladder]]
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| − | **wall usually shows oedema (up to 2cm diameter)
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| | | | |
| − | =====Microscopically=====
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| − | *basophilic intranuclear inclusion bodies
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| − | **in hepatocytes and macrophages
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| | | | |
| | ====Herpes virus infections==== | | ====Herpes virus infections==== |