Changes

[[Image:Thrombopoiesis_pathway.jpg|right|thumb|100px|'''Thrombopoiesis Pathway''']]

[[Image:Thrombopoiesis_pathway.jpg|right|thumb|100px|'''Thrombopoiesis Pathway''']]

===Stem Cell===

===Stem Cell===

As with [[Erythrocytes|erythrocytes]], [[Thrombocytes|thrombocytes]] are derived from multipotential myeloid stem cells ([[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]]). In the [[Bone Marrow - Anatomy & Physiology|bone marrow]] CFU-GEMM cells differentiate into the megakaryocyte precursor cell the megakaryocyte CFU ([[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]]), under the influence of CFU-CSF and IL-3. Unlike other blood cells which undergo mitosis in the first few developmental stages, once the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] has differentiated into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] there is no further mitosis. The [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] then differentiates into the megakaryoblast.  

As with [[Erythrocytes|erythrocytes]], [[Thrombocytes|thrombocytes]] are derived from multipotential myeloid stem cells ([[Haematopoiesis#Colony Forming Units|CFU-GEMM]]). In the [[Bone Marrow - Anatomy & Physiology|bone marrow]] CFU-GEMM cells differentiate into the megakaryocyte precursor cell the megakaryocyte CFU ([[Haematopoiesis#Colony Forming Units|CFU-Meg]]), under the influence of CFU-CSF and IL-3. Unlike other blood cells which undergo mitosis in the first few developmental stages, once the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] has differentiated into the [[Haematopoiesis#Colony Forming Units|CFU-Meg]] there is no further mitosis. The [[Haematopoiesis#Colony Forming Units|CFU-Meg]] then differentiates into the megakaryoblast.  

===Megakaryoblast===

===Megakaryoblast===

Cell is slightly basophilic, around 30µm and has a round nucleus that is non-lobed.

Cell is slightly basophilic, around 30µm and has a round nucleus that is non-lobed.

   

   

====Thrombopoietin ====

====Thrombopoietin ====

Similarly to [[Erythropoiesis#Regulation|erythropoietin]], thrombopoietin (TPO) regulates the production of thrombocytes by stimulating [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] to mature into megakaryocytes. TPO is mainly produced in the liver and acts via a negative feedback system. It binds to TPO receptors on both the megakaryocytes and platelets. Thus if these are in high concentrations in the blood plasma then the level of TPO is kept low, reducing the maturation of [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Meg]] and production of thrombocytes is reduced.

Similarly to [[Erythropoiesis#Regulation|erythropoietin]], thrombopoietin (TPO) regulates the production of thrombocytes by stimulating [[Haematopoiesis#Colony Forming Units|CFU-Meg]] to mature into megakaryocytes. TPO is mainly produced in the liver and acts via a negative feedback system. It binds to TPO receptors on both the megakaryocytes and platelets. Thus if these are in high concentrations in the blood plasma then the level of TPO is kept low, reducing the maturation of [[Haematopoiesis#Colony Forming Units|CFU-Meg]] and production of thrombocytes is reduced.

==Thrombocyte formation==

==Thrombocyte formation==