Difference between revisions of "Azotaemia"
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JamesSwann (talk | contribs) (Created page with '{{unfinished}} ==Description== Azotaemia refers to an increase in the blood concentrations of '''urea''' and '''creatinine'''. Azotaemia occurs almost exclusively with renal fa…') |
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==Clinical Significance== | ==Clinical Significance== | ||
| − | Azotaemia may cause the clinical syndrome of [[Uraemia|'''uraemia''']], affecting multiple organ systems. | + | Azotaemia may cause the clinical syndrome of [[Uraemia|'''uraemia''']], affecting multiple organ systems. The causes of azotaemia are usually divided into pre-renal, renal and post-renal: |
| + | *'''Pre-renal azotaemia''' occurs when the kidney receives insufficient oxygen to maintain its metabolism: | ||
| + | **'''Dehydration/hypovolaemia''', reducing renal blood flow. | ||
| + | **'''Heart failure''' results in a reduced cardiac output, reducing renal blood flow. | ||
| + | **'''Anaemia''' reduces the amount of oxygen delivered to the kidneys. | ||
| + | **'''Portal hypertension''' may result in splanchnic pooling of blood and reduced renal blood flow. | ||
| + | *'''Renal azotaemia''' results from direct insults to the kidney: | ||
| + | **'''Exogenous toxins''' including heavy metals, [[Aminoglycosides|aminoglycosides]], [[Tetracyclines|tetracyclines]], polymixin B, cisplatin, lilies in cats and grapes in dogs. | ||
| + | **'''Endogenous toxins''' including haemoglobin, myoglobin and calcium. | ||
| + | **Infection as in '''pyelonephritis''', '''interstitial nephritis''' (as caused by [[Leptospirosis - Cats and Dogs|''Leptospira spp.'']] or '''granulomatous nephritis''' (as caused by the dry form of [[Feline Infectious Peritonitis]]). | ||
| + | **'''Glomerulonephritis''' and '''[[Amyloidosis|amyloidosis]]'''. | ||
| + | **'''Neoplasia''', including adenocarcinoma in dogs and lymphoma in cats. | ||
| + | *'''Post-renal azotaemia''' results from obstructions to the urinary tract: | ||
| + | **'''[[Urolithiasis - Small Animal|Urolithiasis]]''' | ||
| + | **'''Rupture of the urinary tract''', often due to trauma and causing [[Uroabdomen|uroabdomen]]. | ||
| + | **'''Neoplasia'''. | ||
[[Category:To_Do_-_James]][[Category:Dog]][[Category:Cat]][[Category:Horse]][[Category:Donkey]][[Category:Pig]][[Category:Sheep]][[Category:Cattle]][[Category:Blood_Sample]] | [[Category:To_Do_-_James]][[Category:Dog]][[Category:Cat]][[Category:Horse]][[Category:Donkey]][[Category:Pig]][[Category:Sheep]][[Category:Cattle]][[Category:Blood_Sample]] | ||
Revision as of 13:53, 24 July 2010
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This article is still under construction. |
Description
Azotaemia refers to an increase in the blood concentrations of urea and creatinine. Azotaemia occurs almost exclusively with renal failure that results in an inability to excrete these two metabolic products.
Clinical Significance
Azotaemia may cause the clinical syndrome of uraemia, affecting multiple organ systems. The causes of azotaemia are usually divided into pre-renal, renal and post-renal:
- Pre-renal azotaemia occurs when the kidney receives insufficient oxygen to maintain its metabolism:
- Dehydration/hypovolaemia, reducing renal blood flow.
- Heart failure results in a reduced cardiac output, reducing renal blood flow.
- Anaemia reduces the amount of oxygen delivered to the kidneys.
- Portal hypertension may result in splanchnic pooling of blood and reduced renal blood flow.
- Renal azotaemia results from direct insults to the kidney:
- Exogenous toxins including heavy metals, aminoglycosides, tetracyclines, polymixin B, cisplatin, lilies in cats and grapes in dogs.
- Endogenous toxins including haemoglobin, myoglobin and calcium.
- Infection as in pyelonephritis, interstitial nephritis (as caused by Leptospira spp. or granulomatous nephritis (as caused by the dry form of Feline Infectious Peritonitis).
- Glomerulonephritis and amyloidosis.
- Neoplasia, including adenocarcinoma in dogs and lymphoma in cats.
- Post-renal azotaemia results from obstructions to the urinary tract:
- Urolithiasis
- Rupture of the urinary tract, often due to trauma and causing uroabdomen.
- Neoplasia.