The cytoplasm also contains Plasmids. Plasmids are small circular pieces of DNA that are separate from the genome and are capable of autonomous replication. Several different plasmids can be within the cytoplasm of a single bacteria. Plasmids | The cytoplasm also contains Plasmids. Plasmids are small circular pieces of DNA that are separate from the genome and are capable of autonomous replication. Several different plasmids can be within the cytoplasm of a single bacteria. Plasmids |