Feline Immunodeficiency Virus

Also known as: FIV

Transmission and Epidemiology

Feline Immunodeficiency Virus is commonly abbreviated to FIV

• Unrelated to HIV
• No vaccinal protection between USA Petulama prototype and UK (Hayling Island) isolate

• Cats, including large cats on game reserves
• Transfer via saliva, though usually through a bite (FIV is the disease of enemies)
• Can transfer via milk or mutual grooming in multicat households
• Also transferred via mating
• Particular concern amongst stray males: 3.5% of healthy UK cats are seropositive, but in stray toms, up to 10% are positive
• Four-fold more common in diseased cats than in healthy cats

Pathogenesis

• Receptor: CD134, found on monocyte-derived macrophages and activated T cells
  • Net effect: disruption of acquired immune response
• Infected cats develop antibody whether or not they are able to clear the virus

Two versions:

• Avirulent:
  • Transient infection with no CD4 decline
• Virulent:
  • Progressive CD4 decline with three stages (may present indistinct)
    1. High circulating virus for 1-10 weeks with resulting lymphoid depletion and CD8CD4 double positive Tcell destruction, thymic aplasia esp in kittens
    2. Remission: decrease in circulating virus as immune response increases, followed by immune exhaustion
       • Increase in CD8+ production and antibody response
       • Paracortical T cells and lymphoid follicles expand in primary and secondary lymph tissue and may be visible as white nodules
    3. Rapidly progressing infection with high virus present
       • Feline AIDS presents in a minority of cases
       • Nonregenerative anemia
       • Leucopenia
       • Neutropenia
       • Skin infections
       • Usually followed by secondary infection as a result of immunosuppression
       • Virus-ridden T cell destroy normal T cells, causing chronic immunosuppression

Diagnosis

Laboratory Tests

• ELISA for serum antibody
  • False positives occur, particularly in the presence of maternal Ab
• Positives can be confirmed by lab work (Western blotting)

Pathology

On post-mortem examination, lymphadenopathy is seen. Intestinal lesions similar to those seen in feline panleukopenia virus infection may be apparent^fmc.

In early disease, lymphadenopathy is seen histologically to be due to follicular hyperplasia and infiltration of plasmacytes to surround the cortex. Later in disese, a mixutre of follicular hyperplasia and follicular depletion may exist, and in the terminal stages of FIV infection, follicular involution is the key feature^fmc. Lymphoplasmacytic infiltrates are seen in the gingiva, lymphoid tissues, spleen, kidney, liver and brain. Brain lesions also include perivascular cuffing, gliosis, neuronal loss, vacuolation of the white matter and, occasionally, the presence of giant cells.

Prognosis

The long-term prognosis for FIV-infected cats is guarded, but some cats will survive for many years following diagnosis. Around 20% of affected cats die within the first two years after diagnosis; this equates to a 20% mortality rate in the first 4.5-6 years after the estimated time of infection^fmc. In generally, the more chronic and severe the clinical signs, the worse the prognosis is.

Control

• No UK vaccine
• Healthy positive cats should have diagnose confirmed by further testing
• Isolate and castrate
• Preventative neutering of males

(FIV)

• Lentivirus
• Subtypes A, B and D
• Causes increased susceptibility to infections and neoplasia
• Specifically destroys CD4+ T cells
• Virus is present in saliva, blood and other bodily fluids
• Feral and outdoor cats (mostly tom cats) are most at risk
• Virus replicates in lymphoid tissue
• Can remain asymptomatic
• Causes pyrexia and lymphadenopathy
• Transmitted by biting
• Diagnosis:
  • ELISA
  • Rapid-Immuno-Migration
  • Western Blot
  • Virus Isolation
  • Immunofluorescence
  • PCR
• Treatment:
  • Antibiotics for secondary infection
  • Anti-retroviral therapy
• For vaccinations see here