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Congenital and Neonatal Disease - Pathology
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Revision as of 12:55, 15 February 2011
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12:55, 15 February 2011
→Copper Deficiency
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===Nutritional Deficiencies===
===Nutritional Deficiencies===
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====Copper Deficiency====
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====
[[
Copper Deficiency
]]
====
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* Copper deficiency in the pregnant ewe can result in "''swayback'''" in lambs.
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** Due to white matter degeneration in the central nervous system of prenatal and neonatal lambs.
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* The degeneration is thought to be a mixture of both hypomyelination and demyelination.
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* The central nervous system of the lambs is affected.
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** Neonatal lambs show an ataxia in the first few weeks of life.
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*** Due to demyelination of dorsolateral and ventromedial tracts in the white matter of the spinal cord.
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** More severe lesions can be present in lambs affected prenatally.
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*** Destruction of subcortical white matter in the brain.
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**** The extent of this varies.
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* It is unknown how copper deficiency exerts this effect.
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** Supplementation in pregnancy prevents the prenatal form.
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** Supplementation in the first few weeks will alleviate the neonatal form.
====Vitamin Deficiencies====
====Vitamin Deficiencies====
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