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→Why is it Important?
==Why is it Important?==
==Why is it Important?==
Lysine and lysine-containing compounds, such as hydroxylysine found in collagen; '''play an important role in the secondary structure of [[Protein Overview - Nutrition|proteins]]'''; the positively charged side chain is used for binding to other molecules, such as DNA during replication; and lysine acetylation also plays a role in regulating cellular metabolism<ref name="NRC">National Research Council (NRC). Protein and Amino Acids. In Nutrient Requirements for Dogs and Cats. 2006 Washington, DC: National Academies Press p. 125-126.</ref><ref>Zhao S, et al. Regulation of cellular metabolism by lysine acetylation. Science 2010;327:1000-1004.</ref>.
Lysine and lysine-containing compounds, such as hydroxylysine found in collagen; '''play an important role in the secondary structure of [[Protein Overview - Nutrition|proteins]]'''; the positively charged side chain is used for binding to other molecules, such as [[DNA]] during replication; and lysine acetylation also plays a role in regulating cellular metabolism<ref name="NRC">National Research Council (NRC). Protein and Amino Acids. In Nutrient Requirements for Dogs and Cats. 2006 Washington, DC: National Academies Press p. 125-126.</ref><ref>Zhao S, et al. Regulation of cellular metabolism by lysine acetylation. Science 2010;327:1000-1004.</ref>.
Inherited defects in the transporter for dibasic amino acids can result in poor absorption of lysine (as well as the other dibasic amino acids cystine, ornithine, and [[Arginine - Nutrition|arginine]]) from the intestinal mucosa and poor reabsorption of plasma lysine in the [[Nephron Microscopic Anatomy#Proximal Tubule|renal tubule]]<ref>Hoppe A, et al. Urinary excretion of amino acids in normal and cystinuric dogs. Br Vet J 1993;149:253-68.</ref>.
Inherited defects in the transporter for dibasic amino acids can result in poor absorption of lysine (as well as the other dibasic amino acids cystine, ornithine, and [[Arginine - Nutrition|arginine]]) from the intestinal mucosa and poor reabsorption of plasma lysine in the [[Nephron Microscopic Anatomy#Proximal Tubule|renal tubule]]<ref>Hoppe A, et al. Urinary excretion of amino acids in normal and cystinuric dogs. Br Vet J 1993;149:253-68.</ref>.