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→Morphine
Morphine is a full OP3 agonist, with a 10-15 min onset and a duration of 2-4 hours. Its side effects are as detailed above.
Morphine is a full OP3 agonist, with a 10-15 min onset and a duration of 2-4 hours. Its side effects are as detailed above.
Glucuronidation in the liver produces an active metabolite of the drug, morphine-6-glucuronide (morphine-3-glucuronide is also formed). Metabolites are then excreted in the urine. Enterohepatic circulation of morphine does occur, but this is not clinically important.
Glucuronidation in the liver produces an active metabolite of the drug, morphine-6-glucuronide (morphine-3-glucuronide is also formed). Metabolites are then excreted in the urine. Enterohepatic circulation of morphine does occur, but this is not clinically important.