Author, Donkey, Bureaucrats, Administrators
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*deposition of amyloid in the space of Disse
*deposition of amyloid in the space of Disse
*shows 'apple-green' fluorescence under polarised light after staining with Congo Red
*shows 'apple-green' fluorescence under polarised light after staining with Congo Red
==Arterial==
Amyloid is an eosinophilic, homogenous, hyaline material. Due to its beta-pleated-sheet structure it is almost insoluble. Amyloid may be:
*'''AA''': Serum amyloid A, alpha-2 globulin.
*'''AL''': Derived from immunoglobulin light chains.
Disease may be truly idiopathic (dogs and cats) or may be secondary to another disease process, often chronic inflammation or neoplasia. Chronic antigenic stimulation induces the overproduction of AA protein which may become deposited throughout the body.
Deposits are found:
*Renal vessels and glomeruli.
*Splenic white pulp.
*Space if Disse.
*Coronary arteries.
*Meningeal arteries.
Affected organs are non-functional and appear waxy and pale.
[[Category:Liver_-_Storage_Diseases]]
[[Category:Liver_-_Storage_Diseases]]
[[Category:To_Do_-_Clinical]]
[[Category:Cardiovascular_System_-_Degenerative_Pathology]][[Category:Cardiovascular_System_-_Vascular_Pathology]][[Category:Arterial_Pathology]]