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Measurement of serum glutamate dehydrogenase (GLDH) and/or glutamyl transpeptidase (GGT) levels may prove useful. GLDH is an enzyme released by damaged hepatic cells and becomes elevated within the first few weeks of infection. GGT indicates damage to the epithelial cells lining the bile ducts and rises later in disease, although high levels are maintained for longer. Fluke serology is possible by means of a reliable ELISA test that identifies anti-fluke antibodies in the serum or in milk.
Measurement of serum glutamate dehydrogenase (GLDH) and/or glutamyl transpeptidase (GGT) levels may prove useful. GLDH is an enzyme released by damaged hepatic cells and becomes elevated within the first few weeks of infection. GGT indicates damage to the epithelial cells lining the bile ducts and rises later in disease, although high levels are maintained for longer. Fluke serology is possible by means of a reliable ELISA test that identifies anti-fluke antibodies in the serum or in milk.
===Diagnostic Imaging===
Although not commonly performed in the diagnosis of fasciolosis, ultrasonography can show hepatic changes that may be suggestive of fluke. The probe should be applied immediately caudal to the costal arch, approximately two-thirds of the way down the right hand side. This positioning may reveal an excess of peritoneal exudate and fibrinous adhesions between the liver and the small intestine or the body wall. The liver is seen to be enlarged, and the capsule appears hyperechoic due to fibrin deposition. The liver parenchyma also exhibits changes, appearing diffusely granular, rather than uniformly hypoechoic.
===Biopsy===
===Biopsy===