Changes

Changes in routine haematology and biochemistry may be seen in acute toxoplasmosis. These can include a mild anaemia and leukopenia, as well as increases in liver enzymes.

Changes in routine haematology and biochemistry may be seen in acute toxoplasmosis. These can include a mild anaemia and leukopenia, as well as increases in liver enzymes.

Detection of ''T. gondii''-specific IgG and IgM antibodies by indirect fluorescent antibody tests or ELISA can be used for the diagnosis of human toxoplasmosis. The production of these antibodies follow different time courses: IgM appears in the first two weeks of infection, peaks at 4-8 weeks and declines over the following months, whereas IgG is produced more slowly and remains for months to years. This means that elevations in IgM with low IgG indicates recent ''Toxoplasma gondii'' exposure.  An increased IgG with a low IgM shows previous infection in healthy individuals, and in neonates detection of specific IgM is consistent with congenital infection. This is because while IgG crosses the placenta (and could therefore come from an infected mother), IgM does not and must therefore be produced by the foetus itself.

Indirect fluorescent antibody tests or an ELISA can be used to detect ''T. gondii''-specific IgG and IgM antibodies. The production of these antibodies follow different time courses: IgM appears in the first two weeks of infection, peaks at 4-8 weeks and declines over the following months, whereas IgG is produced more slowly and remains for months to years. Therefore, elevations in IgM alone indicates recent ''Toxoplasma gondii'' exposure, and an increased IgG with low IgM shows previous infection. In neonates, detection of specific IgM is consistent with congenital infection. This is because IgG crosses the placenta and could therefore come from an infected mother, but IgM does not and must therefore be produced by the foetus itself.

===Diagnostic Imaging===

===Diagnostic Imaging===