Nearly all [[NSAIDs]] also potentially induce hepatic injury and this should be considered, particularly when these agents are administered concomitantly with other potentially hepatotoxic agents, such as the [[Potentiated-Sulphonamides|potentiated sulphonamides]]. [[NSAIDs]] should be used with '''particular care in aged animals''', particularly with '''pre-existing renal, cardiac or hepatic disease''', and in cases that are '''dehydrated, in shock or undergoing concurrent therapy with nephrotoxic drugs'''. Particular care is also required when [[NSAIDs]] are administered concurrently with other compounds that are also '''highly protein-bound''', ''e.g.'' the [[Sulphonamides|sulphonamides]]. | Nearly all [[NSAIDs]] also potentially induce hepatic injury and this should be considered, particularly when these agents are administered concomitantly with other potentially hepatotoxic agents, such as the [[Potentiated-Sulphonamides|potentiated sulphonamides]]. [[NSAIDs]] should be used with '''particular care in aged animals''', particularly with '''pre-existing renal, cardiac or hepatic disease''', and in cases that are '''dehydrated, in shock or undergoing concurrent therapy with nephrotoxic drugs'''. Particular care is also required when [[NSAIDs]] are administered concurrently with other compounds that are also '''highly protein-bound''', ''e.g.'' the [[Sulphonamides|sulphonamides]]. |