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Complement Associated Diseases (view source)
Revision as of 09:51, 6 September 2007
, 09:51, 6 September 2007→Alternative Pathway Activation
* C3bB is the only substrate for a plasma enzyme known as Factor D.
* C3bB is the only substrate for a plasma enzyme known as Factor D.
** Factor D splits a small peptide (the Ba peptide) from Factor B.
** Factor D splits a small peptide (the Ba peptide) from Factor B.
*** This splitting generates an active enzyme that splits C3 - <math>\overline {3bBb} \</math>
*** This splitting generates an active enzyme that splits C3 - C3b¯Bb
- C (the bar indicates an active enzyme). C is an enzyme whose substrate is C3, and therefore it generates more C3b - that generates more C - an extremely efficient positive feedback loop. C can also bind C3b to form the complex enzyme; C . This is one of the two enzymes that activates the Membrane Attack Complex (MAC) by splitting C5 into C5a (a small peptide) and C5b (the initiator of the MAC). At the same time the complement inhibitors Factors I and H are acting to breakdown C3b to iC3b (whether as single C3b or in the complex (C ) in plasma or on bacterial surfaces; although iC3b is inactive in participating in the complement cascade it is the major target for phagocytes – as these cells have large numbers of cellular receptors for iC3b (complement receptors) that they use to promote phagocytosis (opsonization).
- C (the bar indicates an active enzyme). C is an enzyme whose substrate is C3, and therefore it generates more C3b - that generates more C - an extremely efficient positive feedback loop. C can also bind C3b to form the complex enzyme; C . This is one of the two enzymes that activates the Membrane Attack Complex (MAC) by splitting C5 into C5a (a small peptide) and C5b (the initiator of the MAC). At the same time the complement inhibitors Factors I and H are acting to breakdown C3b to iC3b (whether as single C3b or in the complex (C ) in plasma or on bacterial surfaces; although iC3b is inactive in participating in the complement cascade it is the major target for phagocytes – as these cells have large numbers of cellular receptors for iC3b (complement receptors) that they use to promote phagocytosis (opsonization).