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Hypothalamus Differences in the Male and Female - Anatomy & Physiology (view source)

Revision as of 17:20, 30 December 2010

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== Defeminizing the Hypothalamus in the Male ==

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* Testosterone crosses the [[Blood Brain Barrier - Anatomy & Physiology|blood-brain barrier]] and is converted into oestradiol.

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Testosterone crosses the [[Blood Brain Barrier - Anatomy & Physiology|blood-brain barrier]] and is converted into oestradiol. In the brain, oestradiol 'defeminizes' the [[Hypothalamus_- Anatomy & Physiology|hypothalamus]] and the surge centre function is minimized. Complete 'defeminization' of the brain requires postnatal exposure to androgens. Continued exposure to androgens is required to render the surge centre inoperative. As a result, LH does not surge, it maintains a relatively consistent episodic pattern of secretion every day. Episodes occur every 2-6 hours in the postpubertal male. Steady, pulsatile GnRH and LH release results in a steady, pulsatile release of [[Testes Endocrine Function_- Anatomy & Physiology|testosterone]].

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* In the brain, oestradiol 'defeminizes' the [[Hypothalamus_- Anatomy & Physiology|hypothalamus]].

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* Surge centre function is minimized.

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* Complete 'defeminization' of the brain requires postnatal exposure to androgens.

−

* Continued exposure to androgens is required to render the surge centre inoperative.

−

* As a result, LH does not surge, it maintains a relatively consistent episodic pattern of secretion every day.

−

** Episodes occur every 2-6 hours in the postpubertal male.

−

* Steady, pulsatile GnRH and LH release results in a steady, pulsatile release of [[Testes Endocrine Function_- Anatomy & Physiology|testosterone]].

== The Female Hypothalamus ==

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