Difference between revisions of "Avian Influenza"

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===Subtypes===
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=== Subtypes ===
*H1-15 and N1-9 have all been isolated
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*H1-15 and N1-9 have all been isolated  
 
*Highly Pathogenic Avian Influenza (HPAI), caused by H5 and H7 isolates, is also known as Fowl Plague (FP) and is notifiable  
 
*Highly Pathogenic Avian Influenza (HPAI), caused by H5 and H7 isolates, is also known as Fowl Plague (FP) and is notifiable  
 
**Chinese poultry are currently the main reservoir for H5N1, not wild birds
 
**Chinese poultry are currently the main reservoir for H5N1, not wild birds
===Pathogenesis===
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*HPAI is defined by:
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=== Pathogenesis ===
**Heamorrhages
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**Diarrhoea
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*HPAI is defined by:  
**Sometimes nervous symptoms
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**Heamorrhages  
**Sudden death
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**Diarrhoea  
*H5 spread by feces and infected viscera (kidney/spleen are 100X more infectious than feces)
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**Sometimes nervous symptoms  
*H7 and other viruses are carried by 6% of the wild bird population and outbreaks mirror migrating patterns
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**Sudden death  
 +
*H5 spread by feces and infected viscera (kidney/spleen are 100X more infectious than feces)  
 +
*H7 and other viruses are carried by 6% of the wild bird population and outbreaks mirror migrating patterns  
 
**This poses significant risk to free-range flocks
 
**This poses significant risk to free-range flocks
===Zoonotic potential===
+
 
*A 2003 Dutch outbreak of a pathogenic H7 virus caused widespread conjunctivitis and flu-like symptoms with recovery among poultry workers
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=== Zoonotic potential ===
 +
 
 +
*A 2003 Dutch outbreak of a pathogenic H7 virus caused widespread conjunctivitis and flu-like symptoms with recovery among poultry workers  
 
*Rural chinese children became infected with H5N1 via aerosol transmission, which was limited to upper respiratory symptoms and did not show horizontal spread
 
*Rural chinese children became infected with H5N1 via aerosol transmission, which was limited to upper respiratory symptoms and did not show horizontal spread
===Control===
+
 
*Prevention by proper hygiene and preventing contact with the wild bird population
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=== Control ===
*Isolation and cull of infected premises
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*Firebreak cull in the case of uncontrolled spread
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*Prevention by proper hygiene and preventing contact with the wild bird population  
*Vaccination is not currently practiced for the following reasons:
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*Isolation and cull of infected premises  
**An eradication policy prevents it
+
*Firebreak cull in the case of uncontrolled spread  
 +
*Vaccination is not currently practiced for the following reasons:  
 +
**An eradication policy prevents it  
 
**Vaccination favors the evolution of the virus, which might increase its virulence and drift
 
**Vaccination favors the evolution of the virus, which might increase its virulence and drift
[[Category:Orthomyxoviridae]][[Category:Poultry]]
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[[Category:To_Do_-_Clinical/Viruses]]
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[[Category:Orthomyxoviridae]] [[Category:Avian Viruses]] [[Category:To_Do_-_Clinical/Viruses]]

Revision as of 16:49, 24 January 2011



Subtypes

  • H1-15 and N1-9 have all been isolated
  • Highly Pathogenic Avian Influenza (HPAI), caused by H5 and H7 isolates, is also known as Fowl Plague (FP) and is notifiable
    • Chinese poultry are currently the main reservoir for H5N1, not wild birds

Pathogenesis

  • HPAI is defined by:
    • Heamorrhages
    • Diarrhoea
    • Sometimes nervous symptoms
    • Sudden death
  • H5 spread by feces and infected viscera (kidney/spleen are 100X more infectious than feces)
  • H7 and other viruses are carried by 6% of the wild bird population and outbreaks mirror migrating patterns
    • This poses significant risk to free-range flocks

Zoonotic potential

  • A 2003 Dutch outbreak of a pathogenic H7 virus caused widespread conjunctivitis and flu-like symptoms with recovery among poultry workers
  • Rural chinese children became infected with H5N1 via aerosol transmission, which was limited to upper respiratory symptoms and did not show horizontal spread

Control

  • Prevention by proper hygiene and preventing contact with the wild bird population
  • Isolation and cull of infected premises
  • Firebreak cull in the case of uncontrolled spread
  • Vaccination is not currently practiced for the following reasons:
    • An eradication policy prevents it
    • Vaccination favors the evolution of the virus, which might increase its virulence and drift