Difference between revisions of "Joint Response to Injury"

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m (Text replace - "[[Disorders of Cell Growth - Pathology" to "[[Cell Growth Disorders")
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***Non-painful
 
***Non-painful
 
**Defects reaching subchondral bone
 
**Defects reaching subchondral bone
***Filled with vascular fibroous tissue undergoing [[Disorders of Cell Growth - Pathology#Metaplasia|metaplasia]] into cartilage
+
***Filled with vascular fibroous tissue undergoing [[Cell Growth Disorders#Metaplasia|metaplasia]] into cartilage
 
***Painful
 
***Painful
 
**Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface  
 
**Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface  

Revision as of 12:49, 15 February 2011


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()Map MUSCULOSKELETAL SYSTEM (Map)
JOINTS



Causes of injury

  • Trauma
  • Instability
  • Lubrication failure
  • Infectious organisms
  • Immune-mediated disease

Reaction to injury

  • Articular cartilage has limited ability to regenerate
    • Superficial defects are long standing
      • Chondrocyte hyperplasia is ineffective at filling the defect
      • Non-painful
    • Defects reaching subchondral bone
      • Filled with vascular fibroous tissue undergoing metaplasia into cartilage
      • Painful
    • Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
    • Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
  • Synovial membranes respond by:
    • Villous hypertrophy
    • Hyperplasia