Difference between revisions of "Degenerations and Infiltrations - Pathology"

Revision as of 14:27, 15 February 2011

Degenerations and infiltrations are the morphological manifestation of an altered metabolism within the cell.
- A particular kind of change within a cell or tissue may suggest that a specific type of alteration has occurred.
Degenerations and infiltrations are types of structural changes.
- These are best considered at a cellular level.
- These structural changes are deviations from the cell's normal structure and function.
  - Parameters are outside the normal physiological range for the cell.
Degeneration
- The tissue cell shows some change in itself.
Infiltration
- Something accumulates in the cell or tissue.

@@ Line 35: / Line 35: @@
-==Cellular Inclusions==
+==[[Cellular Inclusions]]==
-===[[Viruses|Viruses]]===
-* Either in the nucleus or cytoplasm.
-===Storage Products===
-* Due to '''hereditary storage diseases''' in which there is a missing or defective cellular enzyme. There are many types known in domestic animals.
-** Break down/ build up of intracellular substances is halted.
-*** The intermediate substance accumulates in the lysosomes.
-** Affects all tissues
-*** The central nervous system is particularly vulnerable.
-* Due to '''age'''
-** Lysosomes will accumulate non-degradable products
-*** E.g. lipofuscin - the 'ageing' or 'wear and tear pigment'.
-**** Commonly seen in middle-aged cats in the hepatocytes nearest the centrilobular veins.
-===Intracellular Bacteria===
-* For example, [[:Category:Mycobacterium species|''Mycobacterium tuberculosis'']] in macrophages.
-===Protein Accumulation===
-* In the renal tubular epithelium.
-* Occurs when  there is leakage of protein out through a damaged glomerulus.
-[[Category:Degenerations and Infiltrations]]