Changes

Also known as '''Stiff lamb disease''', characterised by myodegeneration.  Disease is stress induced so the breakdown of muscle relies on increased muscle activity.  Muscle degenerates due to a failure to control the free radicals produced by its metabolism upon contraction.  Free radicals damage cellular membranes and proteins.   

Also known as '''Stiff lamb disease''', characterised by myodegeneration.  Disease is stress induced so the breakdown of muscle relies on increased muscle activity.  Muscle degenerates due to a failure to control the free radicals produced by its metabolism upon contraction.  Free radicals damage cellular membranes and proteins.   

**Vitamin E usually mops up OFRs

**Vitamin E usually mops up OFRs

**Selenium as part of glutathione peroxidase neutralises effects of OFRs  

**Selenium as part of glutathione peroxidase neutralises effects of OFRs  

**If Vit E or Se are deficient -> the balance shifts to membrane damage, calcium entry and mitochondrial damage -> cell swells and dies -> segmental muscle [[Muscles Degenerative - Pathology#Necrosis|necrosis]]

**If Vit E or Se are deficient -> the balance shifts to membrane damage, calcium entry and mitochondrial damage -> cell swells and dies -> segmental muscle [[Muscle Necrosis|necrosis]]

*Grossly:

*Grossly:

**Lesions are bilaterally symmetrical in hard working muscles (vary with species)

**Lesions are bilaterally symmetrical in hard working muscles (vary with species)

**Pigs also have lesions in their [[Hyaline Degeneration|heart]] and [[Liver Fibrosis#Hepatosis dietica|liver]]

**Pigs also have lesions in their [[Hyaline Degeneration|heart]] and [[Liver Fibrosis#Hepatosis dietica|liver]]

*Histologically:

*Histologically:

**[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]] +/- [[Muscles Degenerative - Pathology#Calcification|calcification]] and [[Muscle Regeneration|regeneration]]

**[[Muscle Necrosis|Segmental necrosis]] +/- [[Muscle Calcification|calcification]] and [[Muscle Regeneration|regeneration]]

**Multifocal and multiphasic lesions

**Multifocal and multiphasic lesions

[[Category:Muscles - Degenerative Pathology]]

[[Category:Muscles - Degenerative Pathology]]