Difference between revisions of "Muscle Necrosis"
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**Infarction may cause '''discoid degeneration''' - necrotic fibres detach at '''Z lines''' | **Infarction may cause '''discoid degeneration''' - necrotic fibres detach at '''Z lines''' | ||
**May [[Muscle Calcification|mineralise]] | **May [[Muscle Calcification|mineralise]] | ||
| − | *[[Zenker Degeneration | + | *[[Zenker Degeneration|'''Zenker's degeneration''']] - secondary to systemic disease |
**Scattered small segments of necrosis and fast regeneration | **Scattered small segments of necrosis and fast regeneration | ||
**Sacrolemmal tubes are intact | **Sacrolemmal tubes are intact | ||
[[Category:Muscles - Degenerative Pathology]] | [[Category:Muscles - Degenerative Pathology]] | ||
Latest revision as of 22:41, 5 March 2011
- Necrosis of an entire myofibre is uncommon
- Segmental necrosis is more typical
- Muscle cell contents may leak into the blood if the cell membrane is damaged
- Creatine kinase (CK) is an enzyme which leaks following injury
- Used to measure the extent of muscle damage
- Often is followed by regeneration
- Histologically:
- Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining
- May also be an artifact due to hypercontraction of normal fibres at fixation
- Fragmenting portions of fibre -> floccular or granular
- Normal portion of fibre may detach from necrotic part -> retraction caps
- Infarction may cause discoid degeneration - necrotic fibres detach at Z lines
- May mineralise
- Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining
- Zenker's degeneration - secondary to systemic disease
- Scattered small segments of necrosis and fast regeneration
- Sacrolemmal tubes are intact