Difference between revisions of "Corynebacterium species"

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===Pathogenesis and pathogenicity===
 
===Pathogenesis and pathogenicity===
  
*Pyogenic causing  
+
*Pyogenic causing suppurative infections except for ''C. bovis''
 +
*''C. bovis'' causes mild neutrophil response in teat canal of healthy dairy cows and may protect from more pathogenic bacteria
 +
*''C. pseudotuberculosis'':
 +
**Facultative intracellular pathogen inside macrophages
 +
**Cell wall lipid
 +
**Produces a phospholipase toxin which hydolyses sphingomyelin in mammalian cell membranes
 +
**Phospholipase may enhance survival and multiplication in host in early stages
 +
*''C. renale''
 +
**Urinary tract pathogens
 +
**Produce urease and hydrolyse urea
 +
**Possess fimbriae for attachment to urogenital mucosa
 +
**Infection when immunity reduced or following tissue damage during parturition
  
  
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*Infection follows tissue trauma
 
*Infection follows tissue trauma
*Suppurative lesions
 
 
*''C. pseudotuberculosis'' casues caseous lymphadenitis in sheep
 
*''C. pseudotuberculosis'' casues caseous lymphadenitis in sheep
 
*Carried on skin of sheep
 
*Carried on skin of sheep
*Produces a phospholipase toxin
+
 
 
*Infection through shearing wounds
 
*Infection through shearing wounds
*Facultative intracellular pathogen inside macrophages
+
 
 
*Ulcerative lymphangitis in horses
 
*Ulcerative lymphangitis in horses
  

Revision as of 12:20, 18 May 2008

BACK TO INFECTIOUS AGENTS AND PARASITES
BACK TO BACTERIA


  • Corynebacterium pseudotuberculosis may cause myositis
  • Corynebacterium pseudotuberculosis in deep pyoderma

Overview

  • Common inhabitants of skin and mucous membranes of animals
  • Opportunistic infections
  • Cause pyogenic infections
  • Most species host specific


Characteristics

  • Small, tough, Gram positive rods
  • Pleomorphic
  • Cluster together to resemble Chinese characters - coryneform morphology
  • Known as diphtheroids
  • Catalase positive, oxidase negative
  • Facultative anaerobes
  • Require enriched media for growth
  • Non-motile


Pathogenesis and pathogenicity

  • Pyogenic causing suppurative infections except for C. bovis
  • C. bovis causes mild neutrophil response in teat canal of healthy dairy cows and may protect from more pathogenic bacteria
  • C. pseudotuberculosis:
    • Facultative intracellular pathogen inside macrophages
    • Cell wall lipid
    • Produces a phospholipase toxin which hydolyses sphingomyelin in mammalian cell membranes
    • Phospholipase may enhance survival and multiplication in host in early stages
  • C. renale
    • Urinary tract pathogens
    • Produce urease and hydrolyse urea
    • Possess fimbriae for attachment to urogenital mucosa
    • Infection when immunity reduced or following tissue damage during parturition


Clinical infections

  • Infection follows tissue trauma
  • C. pseudotuberculosis casues caseous lymphadenitis in sheep
  • Carried on skin of sheep
  • Infection through shearing wounds
  • Ulcerative lymphangitis in horses


Diagnosis

  • Colony characteristics:
    • C. bovis: lipophilic bacterium; small, white, dry, non-haemolytic colonies on plates inoculated with bovine milk
    • C. kutscheri: white colonies; occasionally haemolytic
    • C. pseudotuberculosis: small, white coloniess surrounded by narrow zone of complete haemolysis; colonies become dry and cream-coloured
    • C. renale: small, non-haemolytic colonies after 24 hours; pigment produced after 48 hours
  • Biochemical reactions:
    • Certain strains of C. pseudotuberculosis reduce nitrates
    • All pathogenic strains except C. bovis produce urease
  • Enhancement of haemolysis produced by C. pseudotuberculosis when inoculated across a streak of Rhodococcus equi