Difference between revisions of "Clostridium species"
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<big><center>[[Bacteria|'''BACK TO BACTERIA''']]</center></big> | <big><center>[[Bacteria|'''BACK TO BACTERIA''']]</center></big> | ||
− | == | + | ===Overview=== |
+ | |||
+ | *Organisms present in the soil, alimentary tract and faeces | ||
+ | *Endospores may be present in liver and may be reactivated to cause disease | ||
+ | *Neurotoxic clostridia, ''Clostridium tetani'' and ''Clostridium botulinum'' affect neuromuscular function but cause no tissue damage | ||
+ | *Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia | ||
+ | *''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemia | ||
+ | |||
+ | ===Characteristics=== | ||
+ | |||
+ | *Large Gram-positive rods | ||
+ | *Obligate anaerobes | ||
+ | *Fermentative, catalase negative, oxidase negative | ||
+ | *Straight or slightly curved | ||
+ | *Motile by flagellae | ||
+ | *Require enriched media for growth | ||
+ | *Produce endospores which vary in shape and location and cause bulging of mother cell | ||
+ | |||
+ | |||
+ | ===Pathogenesis and pathogenicity=== | ||
+ | |||
+ | *''C. perfringens'' colonies are surrounded by a zone of double haemolysis | ||
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===Clostridium botulinum=== | ===Clostridium botulinum=== |
Revision as of 14:05, 18 May 2008
Overview
- Organisms present in the soil, alimentary tract and faeces
- Endospores may be present in liver and may be reactivated to cause disease
- Neurotoxic clostridia, Clostridium tetani and Clostridium botulinum affect neuromuscular function but cause no tissue damage
- Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
- C. perfringens cause inflammatory lesions in the gastrointestinal tract and enterotoxaemia
Characteristics
- Large Gram-positive rods
- Obligate anaerobes
- Fermentative, catalase negative, oxidase negative
- Straight or slightly curved
- Motile by flagellae
- Require enriched media for growth
- Produce endospores which vary in shape and location and cause bulging of mother cell
Pathogenesis and pathogenicity
- C. perfringens colonies are surrounded by a zone of double haemolysis
Clostridium botulinum
- Clostridium botulinum has been implicated in equine grass sickness.
- The toxin also causes botulism, a disease affecting muscle at the neuromuscular junction.
Clostridium chauvei
- Causes gas gangrene, along with Clostridium septicum.
- Infects muscles giving black leg myositis
Clostridium novyi
- Causes gas gangrene and myositis.
- May be involved in cutaneous lesions
Clostridium perfringens
- Causes:
- Lamb dysentery
- Colitis X.
- Pulpy kidney disease
- C. perfringens type D only.
- Peritonitis in cattle
- Dysphagia in horses
- Gas gangrene
- Myositis
Clostridium septicum
- Causes gas gangrene and myositis
Clostridium sordelli
- Causes gas gangrene and myositis
Clostridium tetani
- Clostridium tetani may infect wounds, giving rise to tetanus