Difference between revisions of "Clostridium species"
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<big><center>[[Bacteria|'''BACK TO BACTERIA''']]</center></big> | <big><center>[[Bacteria|'''BACK TO BACTERIA''']]</center></big> | ||
| − | == | + | ===Overview=== |
| + | |||
| + | *Organisms present in the soil, alimentary tract and faeces | ||
| + | *Endospores may be present in liver and may be reactivated to cause disease | ||
| + | *Neurotoxic clostridia, ''Clostridium tetani'' and ''Clostridium botulinum'' affect neuromuscular function but cause no tissue damage | ||
| + | *Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia | ||
| + | *''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemia | ||
| + | |||
| + | ===Characteristics=== | ||
| + | |||
| + | *Large Gram-positive rods | ||
| + | *Obligate anaerobes | ||
| + | *Fermentative, catalase negative, oxidase negative | ||
| + | *Straight or slightly curved | ||
| + | *Motile by flagellae | ||
| + | *Require enriched media for growth | ||
| + | *Produce endospores which vary in shape and location and cause bulging of mother cell | ||
| + | |||
| + | |||
| + | ===Pathogenesis and pathogenicity=== | ||
| + | |||
| + | *''C. perfringens'' colonies are surrounded by a zone of double haemolysis | ||
| − | |||
| − | |||
===Clostridium botulinum=== | ===Clostridium botulinum=== | ||
Revision as of 14:05, 18 May 2008
Overview
- Organisms present in the soil, alimentary tract and faeces
- Endospores may be present in liver and may be reactivated to cause disease
- Neurotoxic clostridia, Clostridium tetani and Clostridium botulinum affect neuromuscular function but cause no tissue damage
- Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
- C. perfringens cause inflammatory lesions in the gastrointestinal tract and enterotoxaemia
Characteristics
- Large Gram-positive rods
- Obligate anaerobes
- Fermentative, catalase negative, oxidase negative
- Straight or slightly curved
- Motile by flagellae
- Require enriched media for growth
- Produce endospores which vary in shape and location and cause bulging of mother cell
Pathogenesis and pathogenicity
- C. perfringens colonies are surrounded by a zone of double haemolysis
Clostridium botulinum
- Clostridium botulinum has been implicated in equine grass sickness.
- The toxin also causes botulism, a disease affecting muscle at the neuromuscular junction.
Clostridium chauvei
- Causes gas gangrene, along with Clostridium septicum.
- Infects muscles giving black leg myositis
Clostridium novyi
- Causes gas gangrene and myositis.
- May be involved in cutaneous lesions
Clostridium perfringens
- Causes:
- Lamb dysentery
- Colitis X.
- Pulpy kidney disease
- C. perfringens type D only.
- Peritonitis in cattle
- Dysphagia in horses
- Gas gangrene
- Myositis
Clostridium septicum
- Causes gas gangrene and myositis
Clostridium sordelli
- Causes gas gangrene and myositis
Clostridium tetani
- Clostridium tetani may infect wounds, giving rise to tetanus