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Intestine

Basic Anatomy and Physiology

Introduction

The intestines are a portion of the alimentary tract extending from the pylorus to the anus. In mammals, the intestines are divided into two main segments: the small intestine and the large intestine. The small intestine, consisting of the duodenum, jejunum and ileum is the main site of absorption for digestive products in the gastrointestinal tract. The large intestine, consisting of the caecum and colon, functions to extract water, electrolytes and nutrients as well as to concentrate and propulse faecal material to the rectum for defaecation. (Dyce et. al, 2002; Young & Heath, 2000).

Functional differences between the small and large intestine are reflected in their anatomic and histologic organisation (Figure 1). The small intestinal mucosa in many species is highly folded and made up of numerous villi that greatly increase the absorptive surface area. Enterocytes, the main absorptive cells, are the most numerous and characteristic cells of the small intestinal epithelium. Other cells include goblet cells, paneth cells, neuroendocrine cells, stem cells, and intraepithelial lymphocytes. Another important feature of the small intestine is the presence of Peyer's patches within the lamina propria. They are important in immune function and generation of immune responses within the mucosa.

In contrast to the small intestine, the large intestinal mucosa has no villi and consists of 2 main cell types: absorptive cells and mucus secreting goblet cells. A distinguishing histologic and anatomic characteristic is the thick muscularis mucosa layer that aids in propulsion of faeces to the rectum. Another important feature of the large intestine is the presence of commensal bacteria which plays different digestive roles depending upon the type of animal.

Defense Mechanisms

Secretions

• Mucus - inhibits contact and protects the mucosal surface
• Digestive enzymes -
• Bile - kills some bacteria and viruses

Epithelium

• "Tight junctions" between epithelial cells prevent entry of macromolecules and pathogens into the intestinal tract.
• Epithelial cells have a very high turnover rate thus preventing pathogens with a longer life cycle from successfully colonising.

Commensal flora

• Commensal flora competitively inhibit attachment of pathogens to enterocytes in addition to competing for nutrition and substrates. Many also produce inhibitory growth substances that are toxic to other bacteria (McGavin and Zachary, 2007.

Movement

• Continuous peristalsis discourages persistence of toxins and aids in their elimination from the gut.

Cell-mediated and humoural defences

• The lamina propria contains macrophages, B and T lymphocytes, plasma cells, and mast cells.
• Lymphoid aggregates known as Peyer's patches within the small intestine aid in immunity.
• Secretory IgA and IgM are important and help prevent attachment of pathogens to the intestinal epithelium.

Comparative

carnivores, ruminants,horse, swine, rabbits [pictures]

References

Dyce KM, Sack WO, Wensing, CJG: Textbook of Veterinary Anatomy, 3rd ed, p. 129. Saunders, London, England, 2002.

McGavin DM & Zachary, JF: Pathologic Basis of Veterinary Disease, 4th ed, pp. 301-393. Elsevier, St. Louis, Missouri, 2007.

Young B, Heath, JW: Wheater's Functional Histology: A Text and Colour Atlas, 4th ed, pp. 249-274. Churchill Livinstone, London, England, 2000.

Pathology of the Large Intestine

Developmental Anomalies

Segmental

describe plus stenosis vs complete (atresia)

Physical Disturbances

Obstruction

describe pathogenesis of can be intraluminal, intramural or extrinsinc (expand on these) include talk about strictures?

Mechanical

Extrinsic

Neoplasia, Adhesions, Prostate enlargement

Functional

Dysautonomia

Grass sickness in horses, Feline

Displacement

Volvulus and Torsion

Ruminants

caecal dilatation and torsion

Equine

right and left dorsal displacement colonic torsion and volvulus

Vascular Disturbances

pathogenesis

Inflammation

pathogenesis

• enteritis
• typhlitis
• colitis
• proctitis

? about subheadings as many fit under specific pathogens notes subcategorising by types of enteritis???

Inflammatory bowel disease

description of

Colitis

Typhlocolitis

in dogs: pipe to species specific section includes histiocytic unlcerative colitis trichuris vulpis, pipe to parasites

Neoplastic and Proliferative Lesions

description

Diarrhoea

definition and pathogenesis characteristics of l.i. diarrhoea

Diseases due to pathogens

Bacteria, Viral, Mycotic brief explanation then pipe to different page

Bacterial

brief explanation

Escherichia coli

description

Salmonellosis

description Link to salmonellosis in specific species

Clostridial enteritis

description

Viral

description Bovine viral diarrhoea Rinderpest Peste des petits ruminants Malignant catarrhal fever Herpesvirus Adenovirus Coronavirus Rotavirus Parvovirus

Mycotic

description Intestinal phycomycosis and aspergillosis Candidiasis Intestinal histoplasmosis

Diseases in Animal Species

Avian

coccidiosis

Carnivores

Cats

Panleucopenia Feline infectious peritonitis Feline leukaemia Feline immunodeficiency virus

Dogs

Parvovirus 2 Distemper Salmonella Rotavirus Coronavirus Ascarids Hookworms Giardiasis Neoplasms Salmon poisoning Haemorrhagic enteritis

Horses

Rhodococcus equi Equine monocytic ehrlichiosis Equine granulomatous enteritis Clostridial enteritis Lawsonian associated Potomac horse fever Parasites Antibiotic associated diarrhoea

Ruminants

Bovine viral diarrhoea Rinderpest Malignant catarrhal fever Paratuberculosis Chlamydiosis Parasitism (list specifics to l.i.) Copper deficiency Salmonellosis Yersiniosis Coccidiosis Escherichia coli Poisoning Winter dysentery

Swine

Rotavirus Transmissible gastroenteritis Escherichia coli Salmonella Lawsonian intracellularis Swine dysentery Porcine circovirus 2 Intestinal spirochaetosis Ascaris suum

Parasites

Cryptosporidiosis Giaridasis Ascariasis Hookworm diseas Trichuriasis Strongyloidosis Pinworms Cestodes Trematodes