Difference between revisions of "Joint Response to Injury"
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===Reaction to injury=== | ===Reaction to injury=== | ||
| − | *[[Joints - | + | *[[Joints - Anatomy & Physiology#Articular cartilage|Articular cartilage]] has limited ability to regenerate |
**Superficial defects are long standing | **Superficial defects are long standing | ||
***Chondrocyte hyperplasia is ineffective at filling the defect | ***Chondrocyte hyperplasia is ineffective at filling the defect | ||
Revision as of 17:23, 5 September 2008
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Causes of injury
- Trauma
- Instability
- Lubrication failure
- Infectious organisms
- Immune-mediated disease
Reaction to injury
- Articular cartilage has limited ability to regenerate
- Superficial defects are long standing
- Chondrocyte hyperplasia is ineffective at filling the defect
- Non-painful
- Defects reaching subchondral bone
- Filled with vascular fibroous tissue undergoing metaplasia into cartilage
- Painful
- Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
- Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
- Superficial defects are long standing
- Synovial membranes respond by:
- Villous hypertrophy
- +/- synovitis
- Hyperplasia
- Villous hypertrophy