Difference between revisions of "Aminoglycosides"
(New page: {{unfinished}} {{toplink |linkpage =WikiDrugs |linktext =WikiDrugs |sublink1 = Antibiotics |subtext1 = Antibiotics |pagetype = Drugs }} ==Mechanism of Action== ==Spectrum of Activi...) |
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| + | This is a large group of antibiotics that are made up of a sugar group and an amino group. As this is a large and diverse group we shall firstly discuss general characteristics and then one by one go through each drug to show and explain their differences. | ||
| + | ==General Group Characteristics== | ||
| + | ===Mechanism of Action=== | ||
| − | + | The drug must first enter the bacterial cell which it does via a oxygen-dependent active transport system. Thus it is unable to work against any anaerobic species. Once inside the cell it disrupts protein synthesis by acting directly on the ribosome. Unlike the other antibiotics that act at the level of protein synthesis these drugs are '''bactericidal''' and are concentration dependent killers. They will act synergistically with any antibiotic that disrupts cell wall synthesis, ie any of the beta-lactams. | |
| + | ===Spectrum of Activity=== | ||
| − | |||
| + | ===Pharmacokinetic Considerations=== | ||
| − | + | Aminoglycosides: Very hydrophilic molecules, weak bases. | |
| + | • Not absorbed from GI tract. | ||
| + | • Distribute poorly (confined to extracellualr fluid mostly – volume of distribution 0.2 l/kg). | ||
| − | ==Side Effects and Contraindications== | + | • Renally excreted – accumulate in proximal tubular cells |
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| + | |||
| + | |||
| + | ===Side Effects and Contraindications=== | ||
Revision as of 15:26, 24 October 2008
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This article is still under construction. |
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This is a large group of antibiotics that are made up of a sugar group and an amino group. As this is a large and diverse group we shall firstly discuss general characteristics and then one by one go through each drug to show and explain their differences.
General Group Characteristics
Mechanism of Action
The drug must first enter the bacterial cell which it does via a oxygen-dependent active transport system. Thus it is unable to work against any anaerobic species. Once inside the cell it disrupts protein synthesis by acting directly on the ribosome. Unlike the other antibiotics that act at the level of protein synthesis these drugs are bactericidal and are concentration dependent killers. They will act synergistically with any antibiotic that disrupts cell wall synthesis, ie any of the beta-lactams.
Spectrum of Activity
Pharmacokinetic Considerations
Aminoglycosides: Very hydrophilic molecules, weak bases. • Not absorbed from GI tract.
• Distribute poorly (confined to extracellualr fluid mostly – volume of distribution 0.2 l/kg).
• Renally excreted – accumulate in proximal tubular cells