Changes

==Signalment==

==Signalment==

Young to middle-aged cats.

Young to middle-aged cats, 50% under 4 years old.

==Description==

==Description==

Lymphocytic cholangitis is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with small lymphocytes.  Although an immune-mediated aetiology has been postulated, the disease has failed to respond to immunosuppressive medications.

Lymphocytic cholangitis is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with inflammatory cells, mostly small lymphocytes.  Although an immune-mediated aetiology has been postulated, the disease has failed to respond to immunosuppressive medications.  It is rarely associated with pancreatitis.

==Diagnosis==

==Diagnosis==

===Clinical Signs===

===Clinical Signs===

History of chronic waxing and waning low-grade illness. Vague clinical signs which include anorexia, depression, weight loss, intermittent vomiting and diarrhoea, jaundice. Severe illness and pyrexia less likely compared to [[Neutrophilic Cholangitis]].  Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.

*History of chronic waxing and waning low-grade illness.

*Vague clinical signs which may include  

**anorexia

**depression, weight loss, intermittent vomiting and diarrhoea, jaundice, lynphadeno  

*Severe illness and pyrexia less likely compared to [[Neutrophilic Cholangitis]].   

*Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.

===Haematology & Biochemistry===

===Haematology & Biochemistry===

Over half of the cats have marked hyperglobulinaemia

*Increased ALP, increased ALT, hyperbilirubinaemia, hyperglobulinaemia

Neutrophilia is less common than with acute cholangitis

*Neutrophilia is less common than with acute cholangitis

===Imaging===

===Imaging===