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Changes
→Histological Appearance of Fatty Change
====Histological Appearance of Fatty Change====
====Histological Appearance of Fatty Change====
In the heart, it
* The fat appears either as globules or is contained in varying sizes of vacuoles in the cytoplasm.
appears as tiny groups of
** In the heart, it appears as tiny groups of vacuoles dispersed along the myofibrils throughout the whole cell.
vacuoles dispersed along
** In the liver and kidney, these vacuoles tend to, but not always, coalesce (come together;
the myofibrils
fuse with one another ) to form larger ones, and you may see one or more large globules filling the cytoplasm with displacement of the nucleus to the periphery of the cell.
throughout the whole
The nucleus remains normal unless the degree of fatty change becomes incompatible with the continued existence of the cell.
cell. In the liver and
kidney, these vacuoles
tend to, but not always,
coalesce (come together;
fuse with one another )
to form larger ones, and
you may see one or
more large globules
filling the cytoplasm
with displacement of the nucleus to the periphery of the cell. The nucleus remains normal
unless the degree of fatty change becomes incompatible with the continued existence of the
cell.
To decide whether or not a vacuole in the cytoplasm of a hepatocyte is fat ( because there are
To decide whether or not a vacuole in the cytoplasm of a hepatocyte is fat ( because there are
two further conditions which may produce vacuoles in hepatocytes, namely the vacuolar
two further conditions which may produce vacuoles in hepatocytes, namely the vacuolar
These sections are over twice as thick as those attained by sectioning paraffin blocks, and so
These sections are over twice as thick as those attained by sectioning paraffin blocks, and so
there may be some overlap of cells on the section, and less clarity of the individual cells.
there may be some overlap of cells on the section, and less clarity of the individual cells.
Causes of 'fatty change'
====Causes of Fatty Change====
1. Dietary and Metabolic
1. Dietary and Metabolic
a. Starvation - this is an increased mobilisation of fat from the body fat stores in response to
a. Starvation - this is an increased mobilisation of fat from the body fat stores in response to