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Changes
→Causes of Fatty Change
=====Dietary and Metabolic=====
=====Dietary and Metabolic=====
energy needs occasioned by a reduction in dietary intake. These are transported in the blood
# '''Starvation'''
as fatty acids, the liver is unable to cope with them all properly, and so they are stored here as
#* A reduction in dietary intake neccessitates the increased mobilisation of fat from body fat stores to meet energy needs.
neutral fats.
#* Fat from stores is transported in the blood as fatty acids.
#** The liver cannot cope with them all properly.
the fat is temporarily stored prior to movement to the body fat stores. It also occurs on a diet
#*** The fatty acids are stored in the liver as neutral fats.
# '''Overeating'''
#* When the dietary intake is greater than the energy expenditure, the fat is temporarily stored prior to movement to the body fat stores.
the liver cells. Some are the amino acids that facilitate conjugation of the fat with proteins to
#** Also occurs in fat-rich diets.
form the lipoprotein that is excreted from the cell, and deficiency of these e.g. choline and
# '''Lipotrope Derangement'''
#* Lipotropes are substances which hasten the removal of fat from the liver cells.
Some poisons e.g. CCl4, phosphorus and alcohol also prevent stages leading to the
#* Lipotropes include the amino acids that allow conjugation of fat with proteins to
form the lipoprotein that is excreted from cells.
#** E.g. choline, methionine.
#** Dietary deficiency of these leads to fatty change within the cells.
#* Some poisons also prevent stages of lipoprotein formation.
#** E.g. CCl4, phosphorus and alcohol
=====Metabolic diseases=====
=====Metabolic diseases=====