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Canine Adenovirus 1 (view source)

Revision as of 13:00, 6 August 2010

547 bytes removed , 13:00, 6 August 2010

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==Viral Characteristics==

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The genetic information of CAV-1, like other Adenoviridae, is conveyed by a single, linear molecule of double-stranded DNA. ~~This~~ is contained within a non-enveloped icosohedral nucleocapsid, which comprises capsomeres (called hexons) and twelve vertex capsomeres (called pentons). A fibre antigen ~~which is used to attach to host cell receptors and initiate replication,~~ protrudes from each of the twelve pentons. This fibre antige is a feature specific to the Adenoviridae.

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The genetic information of CAV-1, like other Adenoviridae, is conveyed by a single, linear molecule of double-stranded DNA which encodes around 30 proteins. Under the influence of both host and virus-encoded factors, the DNA replicates and is transcribed within the host nucleus, where virion assembly also occurs. Basophilic and/or acidophilic inclusions may therefore be seen in the nucleus of an adenovirus-infected cell.

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~~The fiber is the structure of attachment to host cells and is also a type specific hemagglutinin.~~

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The hexon of mammalian adenoviruses contains a cross-reacting group antigen.

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~~The fiber antigen attaches to a specific cell receptor and initiates replication.~~

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The virus genome is contained within a non-enveloped icosohedral nucleocapsid, which comprises capsomeres (called hexons) and twelve vertex capsomeres (called pentons). A fibre antigen protrudes from each of the twelve pentons, and this attaches to host cell receptors as well as being a type-specific haemagglutinin. This fibre antige is a feature specific to the Adenoviridae. The hexon of mammalian adenoviruses contains a cross-reacting group antigen.

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The dsDNA encodes approximately 30 proteins. Viral DNA replication, mRNA transcription and virion assembly occur in the nucleus, utilizing both host and virus-encoded factors. This results in the formation of basophilic and / or acidophilic intranuclear inclusions.

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Many adenoviruses agglutinate red cells of various animal species and some are capable of malignant transformation in tissue culture cell and oncogenesis when inoculated into laboratory animals.

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~~They are resistant to trypsin and lipid solvents, and moderately resistant on premises.~~

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~~Figure 13-1. Adenoviridae (70 - 90 nm). Note the fiber proteins protruding from the vertices of the 12 pentons. To view click on figure~~

==Hosts==

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