* Sydromes caused by clotting factor defects tend to cause more severe bleeding and are usually congenital.
* Sydromes caused by clotting factor defects tend to cause more severe bleeding and are usually congenital.
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=== Haemorrhagic Disease Due To Vascular Fragility===
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[[Vascular Fragility]]
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* There are several ways that vascular fragility may arise.
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# Capillary damage by toxins.
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#* This occurs in severe bacterial infections in all species.
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#* [[:Category:Streptococcus species|''Streptococcus'']] and [[:Category:Pasteurella and Mannheimia species|''Pasteurella'']] infections and [[Bacillus species|anthrax]] can all cause this.
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# Drug-induced damage.
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#* The mechanisms of damage induced by drugs are not clearly understood.
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#* Examples include:
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#** Heavy metals, e.g. lead, bismuth, mercury.
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#** Iodides.
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#** Fluorides.
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#** Chlorinated hydrocarbon pesticides.
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#** Salicylates.
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# Other miscellaneous causes:
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#* Allergy or anaphylactic responses.
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#* Connective tissue disease.
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#** E.g. Ehlers-Danlos syndrome in dogs.
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#* [[DM|Diabetes mellitus]].
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#* Antibody-antigen complex reaction.
===Disease associated with platelet abnormalities===
===Disease associated with platelet abnormalities===