Difference between revisions of "Adenoviridae - Overview"
(Created page with "CAV-1 is a member of the Adenoviridae - Overview family, a group double-stranded DNA viruses with an icosahedral nucleocapsid. Many Adenoviridae have been isolated from mamm...") |
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| + | [[Adenoviridae]] are a group of double-stranded DNA viruses with an icosahedral nucleocapsid. Many Adenoviridae have been isolated from mammals and birds, but only a small number of these cause significant veterinary disease. The family consists of four genera: Mastadenovirus, Aviadenovirus, Atadenovirus and Siadenovirus. [[Canine Adenovirus 1|Canine adenovirus 1]] is a Mastadenovirus. | ||
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==Viral Characteristics== | ==Viral Characteristics== | ||
| − | The genetic information of | + | The genetic information of Adenoviridae is conveyed by a single, linear molecule of double-stranded DNA which encodes around 30 proteins. Under the influence of both host and virus-encoded factors, the DNA replicates and is transcribed within the host nucleus, where virion assembly also occurs. Basophilic and/or acidophilic inclusions may therefore be seen in the nucleus of an adenovirus-infected cell. |
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| + | The virus genome is contained within a non-enveloped icosohedral nucleocapsid, which comprises capsomeres (called hexons) and twelve vertex capsomeres (called pentons). A fibre antigen protrudes from each of the twelve pentons, and this attaches to host cell receptors as well as being a type-specific haemagglutinin. This fibre antigen is a feature specific to the Adenoviridae. The hexon of mammalian adenoviruses contains a cross-reacting group antigen. | ||
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| + | ===Introduction=== | ||
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| + | ===Morphology=== | ||
| + | *Stable, non-enveloped, resistant | ||
| + | *Icosahedral virus: | ||
| + | **Capsomeres at apices (12) carry a peripheral fiber with a terminal knob | ||
| + | **Capsomeres on facets (240) do not | ||
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| − | [[Category:Adenoviridae]] | + | [[Category:Adenoviridae]][[To Do - Lizzie]] |
Revision as of 11:37, 11 August 2010
Adenoviridae are a group of double-stranded DNA viruses with an icosahedral nucleocapsid. Many Adenoviridae have been isolated from mammals and birds, but only a small number of these cause significant veterinary disease. The family consists of four genera: Mastadenovirus, Aviadenovirus, Atadenovirus and Siadenovirus. Canine adenovirus 1 is a Mastadenovirus.
Viral Characteristics
The genetic information of Adenoviridae is conveyed by a single, linear molecule of double-stranded DNA which encodes around 30 proteins. Under the influence of both host and virus-encoded factors, the DNA replicates and is transcribed within the host nucleus, where virion assembly also occurs. Basophilic and/or acidophilic inclusions may therefore be seen in the nucleus of an adenovirus-infected cell.
The virus genome is contained within a non-enveloped icosohedral nucleocapsid, which comprises capsomeres (called hexons) and twelve vertex capsomeres (called pentons). A fibre antigen protrudes from each of the twelve pentons, and this attaches to host cell receptors as well as being a type-specific haemagglutinin. This fibre antigen is a feature specific to the Adenoviridae. The hexon of mammalian adenoviruses contains a cross-reacting group antigen.
Introduction
Morphology
- Stable, non-enveloped, resistant
- Icosahedral virus:
- Capsomeres at apices (12) carry a peripheral fiber with a terminal knob
- Capsomeres on facets (240) do notTo Do - Lizzie