Difference between revisions of "Category:Primary Innate Immunity Deficiencies"

Revision as of 13:46, 12 August 2010

Occurs in Irish Setters
Missence mutation of -Cys-36-Ser- in CD18 molecule
- CD18 is required for neutrophil migration and phagocytosis
Recurrent bacterial infection
Neutrophilia (neutrophils remain in the blood and are unable to fight infection in the tissue)

The following 3 pages are in this category, out of 3 total.

@@ Line 1: / Line 1: @@
 ===Deficiencies of Innate Immunity===
-[[Image:Grey Collie Syndrome.jpg|thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton]]
-====Canine Cyclic Haematopoiesis====
+====[[Canine Cyclic Haematopoiesis]]====
-*Also called '''Grey Collie Syndrome'''
-*Autosomal recessive
-*Insertion mutation in AP3B1 gene
-*Diluted grey coat colour, stunted growth, poor wound healing
-*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]
-*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
-**E.g. pyrexia, [[Diarrhoea|diarrhoea]], gingivitis and arthritis
-*Puppies can be distinguished from other litter mates by the diluted grey colouring
-*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
-*Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth
 ====Canine Leukocyte Adhesion Deficiency (CLAD)====
@@ Line 25: / Line 16: @@
 *Recurrent infection, e.g. pneumonia
-[[Category:Primary Im
+[[Category:Primary Immunodeficiency]]