Difference between revisions of "Selective IgA deficiency of German Shepherd Dogs"
| Line 2: | Line 2: | ||
==Description== | ==Description== | ||
| − | IgA deficiency of German Shepherd dogs is a breed specific lack or reduction of immunoglobulin A caused by a heritable defect | + | IgA deficiency of German Shepherd dogs is a breed specific lack or reduction of immunoglobulin A caused by a heritable defect in the immune system. Dogs which are affected are unable to mount an approapriate immune response and more susceptible to infection and alleric conditions. It has been suggested that the deficiency in IgA is linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis. The condition is poorly understood and the links between IgA deficiency and other conditions has not been fully documented. |
==Signalment== | ==Signalment== | ||
| Line 9: | Line 9: | ||
==Diagnosis== | ==Diagnosis== | ||
===Clinical Signs=== | ===Clinical Signs=== | ||
| + | Clinical signs depend on the level of deficiency but include a high susceptibility to infection, respiratory, gastrointestinal and dermatological conditions. Lethargy, annorexia and failure to thrive are other signs of the condition. | ||
===Laboratory Tests=== | ===Laboratory Tests=== | ||
==Treatment== | ==Treatment== | ||
| + | Affected animals should not be allowed to breed. | ||
==Prognosis== | ==Prognosis== | ||
| − | + | The condition cannot be cured but patients with mild defects can be managed. Secondary infections or symptoms should be addressed where possible. | |
| + | |||
==References== | ==References== | ||
| + | * Blood, D.C. and Studdert, V. P. (1999) '''Saunders Comprehensive Veterinary Dictionary (2nd Edition)''' ''Elsevier Science'' | ||
| + | * Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial'' | ||
| + | * Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier'' | ||
| + | * Tilley, L.P. and Smith, F.W.K.(2004)'''The 5-minute Veterinary Consult (Third edition)''' ''Lippincott, Williams & Wilkins'' | ||
[[Category:Primary Adaptive Immunity Deficiencies]][[Category:Dog]] | [[Category:Primary Adaptive Immunity Deficiencies]][[Category:Dog]] | ||
[[Category:To Do - lizzyk]][[Category:To Do -]] | [[Category:To Do - lizzyk]][[Category:To Do -]] | ||
Revision as of 09:48, 14 September 2010
 |
This article is still under construction. |
Description
IgA deficiency of German Shepherd dogs is a breed specific lack or reduction of immunoglobulin A caused by a heritable defect in the immune system. Dogs which are affected are unable to mount an approapriate immune response and more susceptible to infection and alleric conditions. It has been suggested that the deficiency in IgA is linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis. The condition is poorly understood and the links between IgA deficiency and other conditions has not been fully documented.
Signalment
German Shepherd dogs.
Diagnosis
Clinical Signs
Clinical signs depend on the level of deficiency but include a high susceptibility to infection, respiratory, gastrointestinal and dermatological conditions. Lethargy, annorexia and failure to thrive are other signs of the condition.
Laboratory Tests
Treatment
Affected animals should not be allowed to breed.
Prognosis
The condition cannot be cured but patients with mild defects can be managed. Secondary infections or symptoms should be addressed where possible.
References
- Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition) Elsevier Science
- Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial
- Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier
- Tilley, L.P. and Smith, F.W.K.(2004)The 5-minute Veterinary Consult (Third edition) Lippincott, Williams & Wilkins